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Bhak, Jong
KOrean GenomIcs Center(KOGIC)
Research Interests
  • Geromics, genomics, bioinformatics, protein Engineering, OMICS

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Whole genome comparison of donor and cloned dogs

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Title
Whole genome comparison of donor and cloned dogs
Author
Kim, Hak-MinCho, Yun SungKim, HyunminJho, SungwoongSon, BongjunChoi, Joung YoonKim, SangsooLee, Byeong ChunBhak, Jong HwaJang, Goo
Keywords
CELL NUCLEAR TRANSFER; EMBRYONIC STEM-CELLS; COPY NUMBER; STRUCTURAL VARIATION; MONOZYGOTIC TWINS; TELOMERE LENGTHS; SEQUENCING DATA; DISCORDANT; MUTATION; DISEASE
Issue Date
2013-10
Publisher
NATURE PUBLISHING GROUP
Citation
SCIENTIFIC REPORTS, v.3, no., pp. -
Abstract
Cloning is a process that produces genetically identical organisms. However, the genomic degree of genetic resemblance in clones needs to be determined. In this report, the genomes of a cloned dog and its donor were compared. Compared with a human monozygotic twin, the genome of the cloned dog showed little difference from the genome of the nuclear donor dog in terms of single nucleotide variations, chromosomal instability, and telomere lengths. These findings suggest that cloning by somatic cell nuclear transfer produced an almost identical genome. The whole genome sequence data of donor and cloned dogs can provide a resource for further investigations on epigenetic contributions in phenotypic differences.
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DOI
10.1038/srep02998
ISSN
2045-2322
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BME_Journal Papers
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