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Lee, Jiseok
Novel Optofluidic Materials Synthesis Lab
Research Interests
  • Optofluidic photolithography
  • Nanoparticle Synthesis
  • Conjugated polymer design and Synthesis
  • Flow lithography
  • 3d printing

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Design of Polydiacetylene-Phospholipid Supramolecules for Enhanced Stability and Sensitivity

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Title
Design of Polydiacetylene-Phospholipid Supramolecules for Enhanced Stability and Sensitivity
Author
Kang, Do HyunJung, Ho-SupLee, JiseokSeo, SungbaekKim, JinsangKim, KeesungSuh, Kahp-Yang
Keywords
COLORIMETRIC DETECTION; MOLECULAR RECOGNITION; CHROMATIC TRANSITION; VESICLES; COLOR; SIZE; BIOSENSORS; MEMBRANES; CHROMISM; CHARGE
Issue Date
2012-05
Publisher
AMER CHEMICAL SOC
Citation
LANGMUIR, v.28, no.19, pp.7551 - 7556
Abstract
We present polydiacetylene (PDA) liposome assemblies with various phospholipids that have different head-group charges and phase transition temperatures (T-m). 10,12-Pentacosadiynoic acid (PCDA)-epoxy was used as a base PDA monomer and the insertion of highly charged phospholipids resulted in notable changes in the size of Liposome and reduction of the aggregation of PDA liposome. Among the various phospholipids, the phospholipid with a moderate T-m demonstrated enhanced stability and sensitivity, as measured by the size and zeta potential over storage time, thermochoromic response, and transmission electron microscopy images. By combining these results, we were able to detect immunologically an antibody of bovine viral diarrhea virus over a wide dynamic range of 0.001 to 100 mu g/mL.
URI
https://scholarworks.unist.ac.kr/handle/201301/9594
DOI
10.1021/la300863d
ISSN
0743-7463
Appears in Collections:
ECHE_Journal Papers
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