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Lee, Jiseok
Novel Optofluidic Materials Synthesis Lab
Research Interests
  • Optofluidic photolithography
  • Nanoparticle Synthesis
  • Conjugated polymer design and Synthesis
  • Flow lithography
  • 3d printing

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Biomimetic detection of aminoglycosidic antibiotics using polydiacetylene-phospholipids supramolecules

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Title
Biomimetic detection of aminoglycosidic antibiotics using polydiacetylene-phospholipids supramolecules
Author
Kang, Do HyunJung, Ho-SupAhn, NamyoungLee, JiseokSeo, SungbaekSuh, Kahp-YangKim, JinsangKim, Keesung
Keywords
PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE; COLORIMETRIC DETECTION; VESICLES; NEOMYCIN; INHIBITION; COLOR; ASSAY; MILK
Issue Date
2012
Publisher
ROYAL SOC CHEMISTRY
Citation
CHEMICAL COMMUNICATIONS, v.48, no.43, pp.5313 - 5315
Abstract
We rationally designed highly sensitive and selective polydiacetylene (PDA)-phospholipids liposomes for the facile detection of aminoglycosidic antibiotics. The detecting mechanism mimics the cellular membrane interactions between neomycin and phosphatidylinositol-4,5-bisphosphate (PIP2) phospholipids. The developed PDA-PIP2 sensory system showed a detection limit of 61 ppb for neomycin and was very specific to aminoglycosidic antibodies only.
URI
https://scholarworks.unist.ac.kr/handle/201301/9582
DOI
10.1039/c2cc31466e
ISSN
1359-7345
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ECHE_Journal Papers
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