Biomimetic detection of aminoglycosidic antibiotics using polydiacetylene-phospholipids supramolecules
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- Biomimetic detection of aminoglycosidic antibiotics using polydiacetylene-phospholipids supramolecules
- Kang, Do Hyun; Jung, Ho-Sup; Ahn, Namyoung; Lee, Jiseok; Seo, Sungbaek; Suh, Kahp-Yang; Kim, Jinsang; Kim, Keesung
- PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE; COLORIMETRIC DETECTION; VESICLES; NEOMYCIN; INHIBITION; COLOR; ASSAY; MILK
- Issue Date
- ROYAL SOC CHEMISTRY
- CHEMICAL COMMUNICATIONS, v.48, no.43, pp.5313 - 5315
- We rationally designed highly sensitive and selective polydiacetylene (PDA)-phospholipids liposomes for the facile detection of aminoglycosidic antibiotics. The detecting mechanism mimics the cellular membrane interactions between neomycin and phosphatidylinositol-4,5-bisphosphate (PIP2) phospholipids. The developed PDA-PIP2 sensory system showed a detection limit of 61 ppb for neomycin and was very specific to aminoglycosidic antibodies only.
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