There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 567 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 556 | - |
dc.citation.title | CELL | - |
dc.citation.volume | 148 | - |
dc.contributor.author | Dutchak, Paul A. | - |
dc.contributor.author | Katafuchi, Takeshi | - |
dc.contributor.author | Bookout, Angie L. | - |
dc.contributor.author | Choi, Jang Hyun | - |
dc.contributor.author | Yu, Ruth T. | - |
dc.contributor.author | Mangelsdorf, David J. | - |
dc.contributor.author | Kliewer, Steven A. | - |
dc.date.accessioned | 2023-12-22T05:36:15Z | - |
dc.date.available | 2023-12-22T05:36:15Z | - |
dc.date.created | 2014-10-14 | - |
dc.date.issued | 2012-02 | - |
dc.description.abstract | Fibroblast growth factor-21 (FGF21) is a circulating hepatokine that beneficially affects carbohydrate and lipid metabolism. Here, we report that FGF21 is also an inducible, fed-state autocrine factor in adipose tissue that functions in a feed-forward loop to regulate the activity of peroxisome proliferator-activated receptor gamma (PPAR gamma), a master transcriptional regulator of adipogenesis. FGF21 knockout (KO) mice display defects in PPARg signaling including decreased body fat and attenuation of PPAR gamma-dependent gene expression. Moreover, FGF21-KO mice are refractory to both the beneficial insulin-sensitizing effects and the detrimental weight gain and edema side effects of the PPAR gamma agonist rosiglitazone. This loss of function in FGF21-KO mice is coincident with a marked increase in the sumoylation of PPAR gamma, which reduces its transcriptional activity. Adding back FGF21 prevents sumoylation and restores PPAR gamma activity. Collectively, these results reveal FGF21 as a key mediator of the physiologic and pharmacologic actions of PPAR gamma. | - |
dc.identifier.bibliographicCitation | CELL, v.148, no.3, pp.556 - 567 | - |
dc.identifier.doi | 10.1016/j.cell.2011.11.062 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.scopusid | 2-s2.0-84863012459 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/9465 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84863012459 | - |
dc.identifier.wosid | 000300225000022 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | Fibroblast Growth Factor-21 Regulates PPAR gamma Activity and the Antidiabetic Actions of Thiazolidinediones | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | ACTIVATED-RECEPTOR-GAMMA | - |
dc.subject.keywordPlus | INCREASES ENERGY-EXPENDITURE | - |
dc.subject.keywordPlus | INSULIN SENSITIVITY | - |
dc.subject.keywordPlus | BETA-KLOTHO | - |
dc.subject.keywordPlus | ADIPOCYTE DIFFERENTIATION | - |
dc.subject.keywordPlus | METABOLIC-ACTIVITY | - |
dc.subject.keywordPlus | 3T3 FIBROBLASTS | - |
dc.subject.keywordPlus | HEPATIC FGF21 | - |
dc.subject.keywordPlus | C/EBP-ALPHA | - |
dc.subject.keywordPlus | EXPRESSION | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.