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Choi, Jang Hyun
Lab of Diabetes and Metabolism (LDM)
Research Interests
  • Diabetes, Metabolic Disorders, PPARg, Gene Regulation, Anti-Diabetic Drug


Fibroblast Growth Factor-21 Regulates PPAR gamma Activity and the Antidiabetic Actions of Thiazolidinediones

DC Field Value Language Dutchak, Paul A. ko Katafuchi, Takeshi ko Bookout, Angie L. ko Choi, Jang Hyun ko Yu, Ruth T. ko Mangelsdorf, David J. ko Kliewer, Steven A. ko 2014-12-17T00:16:33Z - 2014-10-14 ko 2012-02 ko
dc.identifier.citation CELL, v.148, no.3, pp.556 - 567 ko
dc.identifier.issn 0092-8674 ko
dc.identifier.uri -
dc.description.abstract Fibroblast growth factor-21 (FGF21) is a circulating hepatokine that beneficially affects carbohydrate and lipid metabolism. Here, we report that FGF21 is also an inducible, fed-state autocrine factor in adipose tissue that functions in a feed-forward loop to regulate the activity of peroxisome proliferator-activated receptor gamma (PPAR gamma), a master transcriptional regulator of adipogenesis. FGF21 knockout (KO) mice display defects in PPARg signaling including decreased body fat and attenuation of PPAR gamma-dependent gene expression. Moreover, FGF21-KO mice are refractory to both the beneficial insulin-sensitizing effects and the detrimental weight gain and edema side effects of the PPAR gamma agonist rosiglitazone. This loss of function in FGF21-KO mice is coincident with a marked increase in the sumoylation of PPAR gamma, which reduces its transcriptional activity. Adding back FGF21 prevents sumoylation and restores PPAR gamma activity. Collectively, these results reveal FGF21 as a key mediator of the physiologic and pharmacologic actions of PPAR gamma. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher CELL PRESS ko
dc.title Fibroblast Growth Factor-21 Regulates PPAR gamma Activity and the Antidiabetic Actions of Thiazolidinediones ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84863012459 ko
dc.identifier.wosid 000300225000022 ko
dc.type.rims ART ko
dc.description.wostc 118 *
dc.description.scopustc 106 * 2015-05-06 * 2014-11-08 *
dc.identifier.doi 10.1016/j.cell.2011.11.062 ko
dc.identifier.url ko
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