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Choi, Jang Hyun
Lab of Diabetes and Metabolism Lab.
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dc.citation.endPage 567 -
dc.citation.number 3 -
dc.citation.startPage 556 -
dc.citation.title CELL -
dc.citation.volume 148 -
dc.contributor.author Dutchak, Paul A. -
dc.contributor.author Katafuchi, Takeshi -
dc.contributor.author Bookout, Angie L. -
dc.contributor.author Choi, Jang Hyun -
dc.contributor.author Yu, Ruth T. -
dc.contributor.author Mangelsdorf, David J. -
dc.contributor.author Kliewer, Steven A. -
dc.date.accessioned 2023-12-22T05:36:15Z -
dc.date.available 2023-12-22T05:36:15Z -
dc.date.created 2014-10-14 -
dc.date.issued 2012-02 -
dc.description.abstract Fibroblast growth factor-21 (FGF21) is a circulating hepatokine that beneficially affects carbohydrate and lipid metabolism. Here, we report that FGF21 is also an inducible, fed-state autocrine factor in adipose tissue that functions in a feed-forward loop to regulate the activity of peroxisome proliferator-activated receptor gamma (PPAR gamma), a master transcriptional regulator of adipogenesis. FGF21 knockout (KO) mice display defects in PPARg signaling including decreased body fat and attenuation of PPAR gamma-dependent gene expression. Moreover, FGF21-KO mice are refractory to both the beneficial insulin-sensitizing effects and the detrimental weight gain and edema side effects of the PPAR gamma agonist rosiglitazone. This loss of function in FGF21-KO mice is coincident with a marked increase in the sumoylation of PPAR gamma, which reduces its transcriptional activity. Adding back FGF21 prevents sumoylation and restores PPAR gamma activity. Collectively, these results reveal FGF21 as a key mediator of the physiologic and pharmacologic actions of PPAR gamma. -
dc.identifier.bibliographicCitation CELL, v.148, no.3, pp.556 - 567 -
dc.identifier.doi 10.1016/j.cell.2011.11.062 -
dc.identifier.issn 0092-8674 -
dc.identifier.scopusid 2-s2.0-84863012459 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/9465 -
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84863012459 -
dc.identifier.wosid 000300225000022 -
dc.language 영어 -
dc.publisher CELL PRESS -
dc.title Fibroblast Growth Factor-21 Regulates PPAR gamma Activity and the Antidiabetic Actions of Thiazolidinediones -
dc.type Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordPlus ACTIVATED-RECEPTOR-GAMMA -
dc.subject.keywordPlus INCREASES ENERGY-EXPENDITURE -
dc.subject.keywordPlus INSULIN SENSITIVITY -
dc.subject.keywordPlus BETA-KLOTHO -
dc.subject.keywordPlus ADIPOCYTE DIFFERENTIATION -
dc.subject.keywordPlus METABOLIC-ACTIVITY -
dc.subject.keywordPlus 3T3 FIBROBLASTS -
dc.subject.keywordPlus HEPATIC FGF21 -
dc.subject.keywordPlus C/EBP-ALPHA -
dc.subject.keywordPlus EXPRESSION -

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