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Son, Jae Sung
Nanomaterials Science and Engineering Lab (NSE)
Research Interests
  • Nanoparticle, 3D printing, Thermoelectrics, Electronics

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Hollow MnOxPy and Pt/MnOxPy yolk/shell nanoparticles as a T1 MRI contrast agent

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Title
Hollow MnOxPy and Pt/MnOxPy yolk/shell nanoparticles as a T1 MRI contrast agent
Author
An, KwangjinNa, Hyon BinPark, Yong IlChoi, Seung HongSon, Jae SungLee, Nohyun
Issue Date
2015-02
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
JOURNAL OF COLLOID AND INTERFACE SCIENCE, v.439, pp.134 - 138
Abstract
Hollow MnOxPy and Pt/MnOxPy yolk/shell nanoparticles were fabricated via the nanoscale acid-etching process from the solid MnO and Pt/MnO core/shell nanoparticles, respectively. In the synthesis, alkylphosphonic acid impurity in trioctylphosphine oxide was a key component, resulting in amorphous hollow metal phosphate nanoparticles. Hollow nanoparticles containing Mn2+ ions showed positively enhanced T1 relaxation, in which the r1 values of the hollow MnOxPy and Pt/MnOxPy yolk/shell were greater than that of the original MnO nanocrystals. The increased surface area of the hollow nanoparticles enhanced interaction between Mn2+ ions of the nanoparticle surface and water molecules. Cytotoxicity experiment revealed that Mn ions released from hollow walls of the MnOxPy nanoparticles were responsible for the cytotoxicity, while Pt ions from the Pt/MnOxPy yolk/shell were not released in the cells. These nanoparticles provide potential insights into an anticancer drug, enabling simultaneous T1 magnetic resonance imaging (MRI) and therapy.
URI
https://scholarworks.unist.ac.kr/handle/201301/9303
URL
http://www.sciencedirect.com/science/article/pii/S0021979714007814
DOI
10.1016/j.jcis.2014.10.027
ISSN
0021-9797
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