Hollow MnOxPy and Pt/MnOxPy yolk/shell nanoparticles as a T1 MRI contrast agent
Cited 0 times inCited 0 times in
- Hollow MnOxPy and Pt/MnOxPy yolk/shell nanoparticles as a T1 MRI contrast agent
- An, Kwangjin; Na, Hyon Bin; Park, Yong Il; Choi, Seung Hong; Son, Jae Sung; Lee, Nohyun
- Issue Date
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- JOURNAL OF COLLOID AND INTERFACE SCIENCE, v.439, pp.134 - 138
- Hollow MnOxPy and Pt/MnOxPy yolk/shell nanoparticles were fabricated via the nanoscale acid-etching process from the solid MnO and Pt/MnO core/shell nanoparticles, respectively. In the synthesis, alkylphosphonic acid impurity in trioctylphosphine oxide was a key component, resulting in amorphous hollow metal phosphate nanoparticles. Hollow nanoparticles containing Mn2+ ions showed positively enhanced T1 relaxation, in which the r1 values of the hollow MnOxPy and Pt/MnOxPy yolk/shell were greater than that of the original MnO nanocrystals. The increased surface area of the hollow nanoparticles enhanced interaction between Mn2+ ions of the nanoparticle surface and water molecules. Cytotoxicity experiment revealed that Mn ions released from hollow walls of the MnOxPy nanoparticles were responsible for the cytotoxicity, while Pt ions from the Pt/MnOxPy yolk/shell were not released in the cells. These nanoparticles provide potential insights into an anticancer drug, enabling simultaneous T1 magnetic resonance imaging (MRI) and therapy.
- Appears in Collections:
- MSE_Journal Papers
- Files in This Item:
- There are no files associated with this item.
can give you direct access to the published full text of this article. (UNISTARs only)
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.