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Advances in MDS/AML and inositide signalling

Author(s)
De Stefano, Alessia, Marvi, Maria Vittoria, Fazio, Antonietta, McCubrey, James A., Suh, Pann-Ghill, Ratti, Stefano, Ramazzotti, Giulia, Manzoli, Lucia, Cocco, Lucio, Follo, Matilde Y.
Issued Date
2023-01
DOI
10.1016/j.jbior.2023.100955
URI
https://scholarworks.unist.ac.kr/handle/201301/91490
Fulltext
https://www.sciencedirect.com/science/article/pii/S2212492623000015?pes=vor&utm_source=clarivate&getft_integrator=clarivate
Citation
ADVANCES IN BIOLOGICAL REGULATION, v.87, pp.100955
Abstract
Aberrant signaling pathways regulating proliferation and differentiation of hematopoietic stem cells (HSCs) can contribute to disease pathogenesis and neoplastic growth. Phosphoinositides (PIs) are inositol phospholipids that are implicated in the regulation of critical signaling pathways: aberrant regulation of Phospholipase C (PLC) beta1, PLCgamma1 and the PI3K/Akt/mTOR pathway play essential roles in the pathogenesis of Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML).
Publisher
ELSEVIER
ISSN
2212-4926
Keyword (Author)
Myelodysplastic syndromes, Acute myeloid leukemia, PI3K, Akt, mTOR, Inositides, Signalling

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