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Soper, Steven A.
Soper Research Group
Research Interests
  • Micro- and nano-fabrication
  • Lab-on-a-chip
  • Polymeric Microfluidic Devices

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Fully Integrated Thermoplastic Genosensor for the Highly Sensitive Detection and Identification of Multi-Drug-Resistant Tuberculosis

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Title
Fully Integrated Thermoplastic Genosensor for the Highly Sensitive Detection and Identification of Multi-Drug-Resistant Tuberculosis
Author
Wang, HongChen, Hui-WenHupert, Mateusz L.Chen, Pin-ChuanDatta, ProyagPittman, Tana L.Goettert, JostMurphy, Michael C.Williams, DianaBarany, FrancisSoper, Steven A.
Keywords
fluorescence; genotyping; microfluidics; tuberculosis
Issue Date
2012
Publisher
WILEY-V C H VERLAG GMBH
Citation
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.51, no.18, pp.4349 - 4353
Abstract
A modular system for the reporting of drug-resistant strains of Mycobacterium tuberculosis (Mtb) in less than 30 min with full process automation was developed (see picture; MDR-TB=multi-drug-resistant tuberculosis). The fluidic cartridge uses a polymer chain reaction (PCR)/ligase detection reaction (LDR)/universal array assay that can detect, with high reliability, resistant strains that are a minority (less than 1%) from a mixed population.
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ISSN
1433-7851
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BME_Journal Papers
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