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Rhee, Hyun-Woo
Biomimetic Chemistry Lab
Research Interests
  • Site-Specific Protein Labeling in Living Cells
  • Artificial Cofactors for Biomimetic Catalyst
  • Spatiotemporal Proteome mapping of living cells

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Detection of Kinase Activity Using Versatile Fluorescence Quencher Probes

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Title
Detection of Kinase Activity Using Versatile Fluorescence Quencher Probes
Author
Rhee, Hyun-WooLee, Settng HwanShin, Ik-SooChoi, So JungPark, Hun HeeHan, KyungjaPark, Tai HyunHong, Jong-In
Keywords
Cancer; Fluorescence; Fluorescent probes; Kinases; Phosphorylation
Issue Date
2010
Publisher
WILEY-V C H VERLAG GMBH
Citation
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.49, no.29, pp.4919 - 4923
Abstract
(Figure Presented) Turn off the light! A kinase assay system employs fluorescent peptides and a phosphate-selective fluorescence quencher probe, and can be placed on a microfluidic chip (see picture). The system can be used for real-time kinase monitoring, kinase inhibitor screening, and cancer diagnosis based on abnormal kinase activity observed in patients' samples.
URI
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DOI
10.1002/anie.201000879
ISSN
1433-7851
Appears in Collections:
PHY_Journal Papers
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