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Ryu, Ja-Hyoung
Supramolecular NanoMaterials Lab (SUN)
Research Interests
  • Supramolecular assembly, synthetic peptide assembly, cancer drug delivery

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Redox-Sensitive Disassembly of Amphiphilic Copolymer Based Micelles

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Title
Redox-Sensitive Disassembly of Amphiphilic Copolymer Based Micelles
Author
Ryu, Ja-HyoungRoy, RaghunathVentura, JudyThayumanavan, S.
Issue Date
2010-05
Publisher
AMER CHEMICAL SOC
Citation
LANGMUIR, v.26, no.10, pp.7086 - 7092
Abstract
Amphiphilic polymers of different hydrophilic-lipophilic ratios were prepared by free radical polymerization using two monomers consisting of triethylene glycol as the hydrophilic part and an alkyl chain connected by disulfide bond as the hydrophobic part. These polymers form micelle-like nanoassemblies in aqueous media and can encapsulate hydrophobic drug molecules up to 14% of their mass. In a reducing environment, these polymeric micelles disassemble and dissolve in water, since the amphiphilic polymers are converted into hydrophilic polymers upon cleavage of the disulfide bond. This disassembly event results in the release of hydrophobic molecules that had been encapsulated inside the micelle, the rate of which was found to be dependent on the concentration of the reducing agent, glutathione (GSH). In vitro experiments also show that the GSH-dependent release of the doxorubicin can be used to effect cytotoxicity in MCF-7 cells.
URI
https://scholarworks.unist.ac.kr/handle/201301/8924
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77952417382
DOI
10.1021/la904437u
ISSN
0743-7463
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CHM_Journal Papers
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