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Ryu, Ja-Hyoung
Supramolecular NanoMaterials Lab (SUN)
Research Interests
  • Supramolecular assembly, synthetic peptide assembly, cancer drug delivery

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Surface-Functionalizable Polymer Nanogels with Facile Hydrophobic Guest Encapsulation Capabilities

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Title
Surface-Functionalizable Polymer Nanogels with Facile Hydrophobic Guest Encapsulation Capabilities
Author
Ryu, Ja-HyoungJiwpanich, SiripornChacko, ReubenBickerton, SeanThayumanavan, S.
Issue Date
2010-06
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.132, no.24, pp.8246 - +
Abstract
The stability of encapsulation in self-assembly systems is limited during blood circulation because of a requisite concentration for assembly formation. For deliberate molecular design for stable encapsulation, targeting, and triggered release, we have developed a facile synthetic method for highly stable, polymeric nanogels using a simple intra/interchain cross-linking reaction. We show a simple, emulsion-free method for the preparation of biocompatible nanogels that provides the ability to encapsulate hydrophobic guest molecules and surface functionalization which has potential for targeted delivery. We show that the noncovalently encapsulated guest molecules can be released in response to a biologically relevant stimulus.
URI
https://scholarworks.unist.ac.kr/handle/201301/8922
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77953633752
DOI
10.1021/ja102316a
ISSN
0002-7863
Appears in Collections:
CHM_Journal Papers
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