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- Kim, Jae-Ick
- Neural Circuit and Neurodegenerative Disease Lab.
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| DC Field | Value | Language |
|---|---|---|
| dc.citation.conferencePlace | KO | - |
| dc.citation.conferencePlace | 인천 송도 컨벤시아 | - |
| dc.citation.title | K-Brain 2025 & The 3rd CJK Neuroscience Meeting | - |
| dc.contributor.author | Lee, Ha-Eun | - |
| dc.contributor.author | Jeong, Minseok | - |
| dc.contributor.author | Lee, Seung Eun | - |
| dc.contributor.author | Kim, Jae-Ick | - |
| dc.date.accessioned | 2025-12-18T13:07:26Z | - |
| dc.date.available | 2025-12-18T13:07:26Z | - |
| dc.date.created | 2025-12-18 | - |
| dc.date.issued | 2025-08-25 | - |
| dc.description.abstract | Theraphenucleiconsistofheterogeneousneuronalpopulations,includingserotonergic,dopaminergic,glutamatergic,andGABAergicneurons.Whilemostresearchontheraphehasfocusedonthemodulatoryroleofserotonergicslowsynaptictransmission—giventhepredominanceofserotonergicneurons—growingevidencehighlightsthesignificanceoffastsynaptictransmissionmediatedbyGABAandglutamate.Inparticular,serotonergicneuronsintheraphenucleihavebeenshowntoco-releaseglutamateinmultiplebrainregions,includingthehippocampus,amygdala,andventraltegmentalarea.Notably,thisglutamatergicco-transmissionoftentargetsinhibitoryinterneuronsratherthanexcitatorycells,especiallywithintheamygdalaandhippocampus.Suchfindingssuggestthatfastexcitatorysignalingfromrapheneuronsmaypreferentiallymodulatelocalinhibitorycircuits,therebyshapingtheactivityofdownstreamnetworks.Inthisstudy,weexaminedthefunctionalroleofraphe-drivenfastsynaptictransmissioninmajorprojectionareasofserotonergicneurons.Bycombiningoptogenetics,immunohistochemistry,andconfocalimaging,weidentifiedthatmultiplebrainregionsreceivedi-synapticinputsfromrapheserotonergicneurons,withthehippocampusshowingthemostsignificantfunctionalconnection.Withinthehippocampus,wediscoveredthatglutamateco-releasefromrapheserotonergicneuronsselectivelyenhancestheexcitabilityofCCK-positiveinhibitoryinterneurons.ThismodulationofCCK-expressingneuronshadadownstreameffectontheexcitabilityofCA1pyramidalneuronsandsignificantlyfacilitatedsynapticplasticityatSchaffercollateral–CA1synapses.Ourfindingsunderscorethefunctionalimportanceofraphe-mediatedglutamateco-transmissionandprovidenewinsightsintotheintricatesynapticmodulationexertedbyrapheserotonergicneuronsinthebrain. | - |
| dc.identifier.bibliographicCitation | K-Brain 2025 & The 3rd CJK Neuroscience Meeting | - |
| dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/89188 | - |
| dc.language | 영어 | - |
| dc.publisher | The Korean Society for Brain and Neural Sciences | - |
| dc.title | Raphe-driven glutamate co-transmission shapes hippocampal function via modulation of cholecystokinin expressing inhibitory neurons | - |
| dc.type | Conference Paper | - |
| dc.date.conferenceDate | 2025-08-24 | - |
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