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Ryu, Ja-Hyoung
Supramolecular NanoMaterials Lab (SUN)
Research Interests
  • Supramolecular assembly, synthetic peptide assembly, cancer drug delivery

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Self-Cross-Linked Polymer Nanogels: A Versatile Nanoscopic Drug Delivery Platform

Cited 149 times inthomson ciCited 131 times inthomson ci
Title
Self-Cross-Linked Polymer Nanogels: A Versatile Nanoscopic Drug Delivery Platform
Author
Ryu, Ja-HyoungChacko, Reuben T.Jiwpanich, SiripornBickerton, SeanBabu, R. PrakashThayumanavan, S.
Keywords
Breast cancer cells; Cancer therapy; Cross-linked polymers; Cross-linking density; Doxorubicin; Drug molecules; Dye encapsulation; Fluorescence resonance energy transfer; Glutathiones; Guest molecules; Hydrophobic drug; In-vitro; Nanogels; Precursor polymers; Random copolymer; Side-chain functionalities; Stable encapsulation; Therapeutic Application; Tunabilities
Issue Date
2010-12
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.132, no.48, pp.17227 - 17235
Abstract
Nanoscopic vehicles that stably encapsulate drug molecules and release them in response to a specific trigger are of great interest due to implications in therapeutic applications, especially for cancer therapy. For this purpose, we have synthesized highly stable polymeric nanogels, in which the kinetics of guest molecule release can be fine-tuned by control over cross-linking density. The polymer nanogel precursor is based on a random copolymer that contains oligoethyleneglycol (OEG) and pyridyldisulfide (PDS) units as side-chain functionalities. By introducing variations into the precursor polymer, such as molecular weight and the relative percentages of hydrophilic OEG units and hydrophobic PDS functionalities, we have achieved significant control over nanogel size. We show that the noncovalently encapsulated guest molecules can be released in response to a redox trigger, glutathione (GSH). Stability of dye encapsulation inside the nanogels and tunability in the release of guest molecules have been demonstrated through in vitro fluorescence resonance energy transfer (FRET) experiments. We show in vitro doxorubicin delivery into breast cancer cells (MCF-7) with nanogels of different cross-linking density to demonstrate that it plays a key role in the stable encapsulation of hydrophobic drug molecules and the cell-uptake efficiencies.
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DOI
10.1021/ja1069932
ISSN
0002-7863
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PHY_Journal Papers
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