BROWSE

Related Researcher

Author's Photo

Ryu, Ja-Hyoung
Supramolecular NanoMaterials Lab (SUN)
Research Interests
  • Supramolecular assembly, synthetic peptide assembly, cancer drug delivery

ITEM VIEW & DOWNLOAD

Ligand-Decorated Nanogels: Fast One-Pot Synthesis and Cellular Targeting

Cited 19 times inthomson ciCited 16 times inthomson ci
Title
Ligand-Decorated Nanogels: Fast One-Pot Synthesis and Cellular Targeting
Author
Ryu, Ja-HyoungBickerton, SeanZhuang, JiamingThayumanavan, S.
Issue Date
2012-05
Publisher
AMER CHEMICAL SOC
Citation
BIOMACROMOLECULES, v.13, no.5, pp.1515 - 1522
Abstract
Nanoscale vehicles for delivery have been of interest and extensively studied for two decades. However, the encapsulation stability of hydrophobic drug molecules in delivery vehicles and selective targeting these vehicles into disease cells are potential hurdles for efficient delivery systems. Here we demonstrate a simple and fast synthetic protocol of nanogels that shows high encapsulation stabilities. These nanogels can also be modified with various targeting ligands for active targeting. We show that the targeting nanogels (T-NGs), which are prepared within 2 h by a one-pot synthesis, exhibit very narrow size distributions and have the versatility of surface modification with cysteine-modified ligands including folic acid, cyclic arginine-glycine-aspartic acid (cRGD) peptide, and cell-penetrating peptide. T-NGs hold their payloads, undergo facilitated cell internalization by receptor-mediated uptake, and release their drug content inside cells due to the reducing intracellular environment. Selective cytotoxicity to cells, which have complementary receptors, is also demonstrated.
URI
https://scholarworks.unist.ac.kr/handle/201301/8908
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84861167199
DOI
10.1021/bm300201x
ISSN
1525-7797
Appears in Collections:
CHM_Journal Papers
Files in This Item:
There are no files associated with this item.

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU