—A proposed chest patch device and its interface IC are configured to allow detection of multi-domain signals in the form of optical, electrical, acoustic, and chemical signals at a single body spot. The IC integrates on-chip classification capabilities for cardiovascular diseases based on photoplethysmogram (PPG) and electrocardiogram (ECG), along with hazardous gas analysis. For low-power multimodal sensing, an ECG R-peak triggered PPG window (RPT-PW) is proposed as an inter-sensor scheme to reduce activity on the PPG channel, which is the dominant energy consumer. Additionally, the PPG and ECG readout channels incorporate analog peak detection to enable normalized on-chip extraction of pulse arrival time (PAT) and R-R interval (RRI). For minimal computation and communication power, a multi-domain convolutional neural network (MD-CNN) processes both analog and digital inputs, and a reconfigurable analog ternary/binary neural network (aTNN/BNN) provides additional computation capability for multidomain applications. The IC was fabricated in an 180-nm BCD process and integrated into a chest patch device prototype with an in-house adhesive meta patch. The RPT-PW demonstrated adaptive operation with an effective LED duty cycle as low as 0.02%. The on-chip computation achieved average sensitivity and specificity of 90.87%/95.38% for three-label hypertension, 92.80%/96.36% for three-label arrhythmia, and 92.46%/97.50% for four-label gas mixture classification.