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Kim, Yung Sam
Ultrafast 2D IR Spectroscopy Lab
Research Interests
  • 2D IR, chemical exchange of H-bond, fast reaction dynamics, protein dynamics


2D IR provides evidence for mobile water molecules in beta-amyloid fibrils

DC Field Value Language Kim, Yung Sam ko Liu, Liu ko Axelsen, Paul H. ko Hochstrasser, Robin M. ko 2014-11-17T08:07:54Z - 2014-11-14 ko 2009-10 ko
dc.identifier.citation PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.106, no.42, pp.17751 - 17756 ko
dc.identifier.issn 0027-8424 ko
dc.identifier.uri -
dc.description.abstract The motion of water molecules close to amide groups causes their vibrational frequencies to vary rapidly in time. These variations are uniquely sensed by 2-dimensional infrared spectroscopy (2D IR). Here, it is proposed from 2-dimensional experiments on fibrils of amyloid β (Aβ)40 that there are water molecules in the fibrils. The spatial locations of the water (D 2O) were inferred from the responses of 18 amide modes of Aβ40 labeled with 13C = 18O. Fast frequency variations were found for residues L17 and V18 and for the apposed residues L34 and V36, suggesting cavities or channels containing mobile water molecules can form between the 2 sheets. Spectroscopic analysis showed that there are 1.2 water molecules per strand in the fibrils. The 13C = 18O substitution of 1 residue per strand creates a linear array of isotopologs along the fibril axis that manifests clearly identifiable vibrational transitions. Here, it is shown from the distributions of amide-I′ vibrational frequencies that the regularity of these chains is strongly residue dependent and in most cases the distorted regions are also those associated with the putative mobile water molecules. It is proposed that Aβ40 fibrils contain structurally significant mobile water molecules within the intersheet region. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher NATL ACAD SCIENCES ko
dc.title 2D IR provides evidence for mobile water molecules in beta-amyloid fibrils ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-70449584579 ko
dc.identifier.wosid 000270963100029 ko
dc.type.rims ART ko
dc.description.wostc 73 *
dc.description.scopustc 32 * 2015-05-06 * 2014-11-14 *
dc.identifier.doi 10.1073/pnas.0909888106 ko
dc.identifier.url ko
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