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Kim, Byeong-Su
Soft and Hybrid Nanomaterials Lab
Research Interests
  • Carbon materials, polymer, Layer-by-Layer (LbL) assembly, hyperbranched polymer, polyglycerol (PG), bio-applications

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Bactericidal and virucidal ultrathin films assembled layer by layer from polycationic N-alkylated polyethylenimines and polyanions

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Title
Bactericidal and virucidal ultrathin films assembled layer by layer from polycationic N-alkylated polyethylenimines and polyanions
Author
Wong, Sze YinnLi, QingVeselinovic, JovanaKim, Byeong-SuKlibanov, Alexander M.Hammond, Paula T.
Keywords
Bactericidal; Contact-killing; Layer-by-Layer (LbL); Microbicidal; Polyelectrolyte multilayer; Virucidal
Issue Date
2010-05
Publisher
ELSEVIER SCI LTD
Citation
BIOMATERIALS, v.31, no.14, pp.4079 - 4087
Abstract
In this work, we designed contact-killing ionically cross-linked polymeric thin films using Layer-by-Layer (LbL) technology. A polycation, N,N-dodecyl,methyl-polyethylenimine, with microbicidal activity was layered with a polyanion, such as poly(acrylic acid), to create LbL films highly effective against both airborne and waterborne Escherichia coli and Staphylococcus aureus (Gram negative and positive bacteria, respectively), as well as influenza A/WSN (H1N1) virus. The dependence of the microbicidal activity on the pH during and post-assembly of LbL film formation, the nature of the polycation and polyanion, the number of layers in the LbL film, and other experimental variables was investigated quantitatively.
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DOI
10.1016/j.biomaterials.2010.01.119
ISSN
0142-9612
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PHY_Journal Papers
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