dc.citation.endPage |
256 |
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dc.citation.number |
3 |
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dc.citation.startPage |
253 |
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dc.citation.title |
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES |
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dc.citation.volume |
1027 |
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dc.contributor.author |
Kwon, H. Moo |
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dc.date.accessioned |
2023-12-22T13:09:05Z |
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dc.date.available |
2023-12-22T13:09:05Z |
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dc.date.created |
2014-11-13 |
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dc.date.issued |
1990-09 |
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dc.description.abstract |
Basolateral membrane vesicles made from rabbit kidney proximal tubules were frozen and irradiated with a high energy electron beam and the effects of irradiation on Na,K-ATPase activity, p-aminohippurate (PAH) transport, the membrane diffusion barrier and vesicle volume were measured. The vesicle volume and diffusion barrier were not significantly changed by radiation exposure. Na,K-ATPase activity was inactivated as a simple exponential function of radiation dose. Target size analysis of the data yielded a molecular size of 267 ± 17 kDa, consistent with its existence as a (αβ)2 dimer. The carrier-mediated PAH uptake by basolateral membrane vesicles was also inactivated as a function of radiation dose. A target molecular size of 74 ± 16 kDa was calculated for the PAH transport system. This study is the first measurement of the functional size of the organic acid transport system based directly on flux measurements. |
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dc.identifier.bibliographicCitation |
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v.1027, no.3, pp.253 - 256 |
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dc.identifier.issn |
0005-2736 |
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dc.identifier.scopusid |
2-s2.0-0025145735 |
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dc.identifier.uri |
https://scholarworks.unist.ac.kr/handle/201301/8809 |
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dc.identifier.url |
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0025145735 |
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dc.identifier.wosid |
A1990DZ24000007 |
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dc.language |
영어 |
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dc.publisher |
ELSEVIER SCIENCE BV |
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dc.title |
RADIATION TARGET SIZES OF THE NA,K-ATPASE AND PARA-AMINOHIPPURATE TRANSPORT-SYSTEM IN THE BASOLATERAL MEMBRANE OF RENAL PROXIMAL TUBULE |
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dc.type |
Article |
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dc.description.journalRegisteredClass |
scopus |
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