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Kim, Kyoung Taek
KT Kim Group at UNIST
Research Interests
  • Polymer Chemistry
  • Organic Chemistry
  • Supramolecular Chemistry
  • Biopolymers

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Synthesis and micellar characteristics of dendron-PEG conjugates

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Title
Synthesis and micellar characteristics of dendron-PEG conjugates
Author
Chang, YPark, CKim, Kyoung TaekKim, C
Keywords
POLYSTYRENE-POLY(PROPYLENE IMINE) DENDRIMERS; DENDRITIC DIBLOCK COPOLYMERS; LINEAR BLOCK-COPOLYMERS; DEPENDENT AGGREGATION; POLYETHER DENDRIMERS; FUNCTIONAL POLYMERS; CHEMISTRY; OXIDE); POLY(2-ETHYL-2-OXAZOLINE); L-ASPARTATE)
Issue Date
2005-05
Publisher
AMER CHEMICAL SOC
Citation
LANGMUIR, v.21, no.10, pp.4334 - 4339
Abstract
Urethane-amide dendrons of up to the third generation were synthesized via a convergent route. These dendrons were coupled with MeO-PEG (Mn = 2000), and the micellar characteristics of dendron-PEG conjugates in water were investigated. The conjugates with the second or third generation dendron (PEG-2GOc and PEG-3Oc) formed micellar aggregates in an aqueous phase. However, the conjugate with the first generation dendron (PEG-1GOc) did not exhibit micellar aggregates detectable by dynamic light scattering possibly due to the high ratio of the hydrophilic moiety to hydrophobic periphery. The critical aggregation concentrations of PEG-2GOc and PEG-3GOc determined by fluorescence techniques were 7.5 and 2.0 mg/L, respectively. The mean diameters of the micelles of PEG-2GOc and PEG-3GOc, measured by dynamic light scattering, were 90 and 170 nm. The partition equilibrium constants (Kv) of pyrene in the micellar solution increased by increasing the size of the dendritic block, for example, 6.17 × 104 for PEG-2GOc and 1.58 × 10 5 for PEG-3GOc. The steady-state fluorescence anisotropy values (r) of 1,6-diphenyl-1,3,5-hexatriene (DPH) were 0.107 for PEG-2GOc and 0.178 for PEG-3GOc. When the third generation dendritic moiety is incorporated into the conjugates, the Kv and r values become comparable to those for typical block copolymer micelles.
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DOI
10.1021/la047036f
ISSN
0743-7463
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PHY_Journal Papers
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