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Kim, Kyoung Taek
KT Kim Group at UNIST
Research Interests
  • Polymer Chemistry
  • Organic Chemistry
  • Supramolecular Chemistry
  • Biopolymers

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Metallopolymer-peptide conjugates: Synthesis and self-assembly of polyferrocenylsilane graft and block copolymers containing a beta-sheet forming Gly-Ala-Gly-Ala tetrapeptide segment

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Title
Metallopolymer-peptide conjugates: Synthesis and self-assembly of polyferrocenylsilane graft and block copolymers containing a beta-sheet forming Gly-Ala-Gly-Ala tetrapeptide segment
Author
Vandermeulen, GWMKim, Kyoung TaekWang, ZManners, I
Keywords
WALLED CARBON NANOTUBES; POLYMERS; METAL; POLY(FERROCENYLSILANES); POLYMERIZATION; PHENOXATHIIN; TRANSITION; DENSITY; ROUTES; HELIX
Issue Date
2006-04
Publisher
AMER CHEMICAL SOC
Citation
BIOMACROMOLECULES, v.7, no.4, pp.1005 - 1010
Abstract
We describe the synthesis and self-assembly of two β-sheet forming metallopolymer-peptide conjugates. The ability of the oligotetrapeptide sequence Gly-Ala-Gly-Ala (GAGA) to form antiparallel β-sheets was retained in PFS-b-AGAG (PFS = polyferrocenylsilane) and PFS-g-AGAG conjugates with block and graft architectures, respectively. In the solid state, DSC experiments suggest a phase separation between the peptide and PFS domains. In toluene, PFS-b-AGAG interestingly forms a fibrous network which consists of a core containing the self-assembled antiparallel β-sheet peptide and a corona of organometallic PFS. The self-assembly of the peptide into antiparallel β-sheets is the driving force for the fiber formation, whereas PFS prevents uncontrolled lateral aggregation of the fibers. The use of an oligopeptide to self-assemble an otherwise random coiled organometallic polymer may be a useful strategy to enhance nanostructure formation. In the cases described here, the conjugates may be used to create nanopatterned ceramics, and the redox properties of the resulting supramolecular aggregates are of significant interest.
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DOI
10.1021/bm050732p
ISSN
1525-7797
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PHY_Journal Papers
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