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Kwon, Oh Hoon
Ultrafast Laser Spectroscopy and Nano-microscopy (ULSaN Lab)
Research Interests
  • Femtochemistry/biology, 4D electron microscopy, structural dynamics, materials phenomena

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Hydration dynamics at fluorinated protein surfaces

Cited 25 times inthomson ciCited 23 times inthomson ci
Title
Hydration dynamics at fluorinated protein surfaces
Author
Kwon, Oh HoonYoo, Tae HyeonOthona, Christina M.Van Deventer, James A.Tirrell, David A.Zewail, Ahmed H.
Issue Date
2010-10
Publisher
NATL ACAD SCIENCES
Citation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.107, no.40, pp.17101 - 17106
Abstract
Water-protein interactions dictate many processes crucial to protein function including folding, dynamics, interactions with other biomolecules, and enzymatic catalysis. Here we examine the effect of surface fluorination on water-protein interactions. Modification of designed coiled-coil proteins by incorporation of 5,5,5-trifluoroleucine or (4S)-2-amino-4-methylhexanoic acid enables systematic examination of the effects of side-chain volume and fluorination on solvation dynamics. Using ultrafast fluorescence spectroscopy, we find that fluorinated side chains exert electrostatic drag on neighboring water molecules, slowing water motion at the protein surface.
URI
https://scholarworks.unist.ac.kr/handle/201301/8730
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78049299552
DOI
10.1073/pnas.1011569107
ISSN
0027-8424
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CHM_Journal Papers
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