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Kwon, Oh Hoon
Ultrafast Laser Spectroscopy and Nano-microscopy (ULSaN Lab)
Research Interests
  • Femtochemistry/biology, 4D electron microscopy, structural dynamics, materials phenomena

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Macromolecular structural dynamics visualized by pulsed dose control in 4D electron microscopy

Cited 11 times inthomson ciCited 10 times inthomson ci
Title
Macromolecular structural dynamics visualized by pulsed dose control in 4D electron microscopy
Author
Kwon, Oh HoonOrtalan, VolkanZewail, Ahmed H.
Issue Date
2011-04
Publisher
NATL ACAD SCIENCES
Citation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.108, no.15, pp.6026 - 6031
Abstract
Macromolecular conformation dynamics, which span a wide range of time scales, are fundamental to the understanding of properties and functions of their structures. Here, we report direct imaging of structural dynamics of helical macromolecules over the time scales of conformational dynamics (ns to subsecond) by means of four-dimensional (4D) electron microscopy in the single-pulse and stroboscopic modes. With temporally controlled electron dosage, both diffraction and real-space images are obtained without irreversible radiation damage. In this way, the order-disorder transition is revealed for the organic chain polymer. Through a series of equilibrium-temperature and temperature-jump dependencies, it is shown that the metastable structures and entropy of conformations can be mapped in the nonequilibrium region of a "funnellike" free-energy landscape. The T-jump is introduced through a substrate (a "hot plate" type arrangement) because only the substrate is made to absorb the pulsed energy. These results illustrate the promise of ultrafast 4D imaging for other applications in the study of polymer physics as well as in the visualization of biological phenomena.
URI
https://scholarworks.unist.ac.kr/handle/201301/8729
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79954995496
DOI
10.1073/pnas.1103109108
ISSN
0027-8424
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CHM_Journal Papers
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