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Lim, Mi Hee
MetalloNeuroChemistry Lab (MNCL)
Research Interests
  • Neurodegenerative disease, small molecule design, network between metal, proteins, and ROS

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Nitric oxide-induced fluorescence enhancement by displacement of dansylated ligands from cobalt

Cited 22 times inthomson ciCited 24 times inthomson ci
Title
Nitric oxide-induced fluorescence enhancement by displacement of dansylated ligands from cobalt
Author
Lim, Mi HeeKuang, ChaoyuanLippard, Stephen J.
Keywords
Cobalt; Dyes; Fluorescence; Nitric Oxide; Sensors
Issue Date
2006-10
Publisher
WILEY-V C H VERLAG GMBH
Citation
CHEMBIOCHEM, v.7, no.10, pp.1571 - 1576
Abstract
The cobalt complexes [Co(Ds-AMP)2] (1) and [Co(Ds-AQ) 2] (2), where Ds-AMP and Ds-AQ are the conjugate bases of dansyl aminomethylpyridine (Ds-HAMP) and dansyl aminoquinoline (Ds-HAQ), respectively, were synthesized in two steps as fluorescence-based nitric oxide (NO) sensors and characterized by X-ray crystallography. The fluorescence of the two complexes was significantly quenched in CH3CN or CH3OH compared to that of the free Ds-HAMP or Ds-HAQ ligands. Addition of NO to a CH3CN solution of 1 or 2 enhanced the integrated fluorescence emission by factors of 2.1(+0.3) or 3.6(+0.4) within 35 or 20 min, respectively. Introduction of NO to methanolic solutions of the complexes similarly increased the fluorescence by 1.4(±0.1) for 1 or 6.5(±1.4) for 2 within 1 h. These studies demonstrate that 1 and 2 can monitor the presence of NO with turn-on emission and that their fluorescence responses are more rapid than those of previously reported cobalt systems in coordinating solvents such as CH 4CN and CH3OH. 1H NMR and IR spectroscopic data revealed the formation of a {Co(NO)2}10 cobalt-dinitrosyl adduct, with concomitant dissociation of one ligand from the cobalt center, as the metal-containing product of the NO reactions, a result indicating NO-induced ligand release to be the cause of the fluorescence increase.
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DOI
10.1002/cbic.200600042
ISSN
1439-4227
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PHY_Journal Papers
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