BROWSE

Related Researcher

Author's Photo

Lim, Mi Hee
MetalloNeuroChemistry Lab (MNCL)
Research Interests
  • Neurodegenerative disease, small molecule design, network between metal, proteins, and ROS

ITEM VIEW & DOWNLOAD

Fluorescent nitric oxide detection by copper complexes bearing anthracenyl and dansyl fluorophore ligands

Cited 44 times inthomson ciCited 9 times inthomson ci
Title
Fluorescent nitric oxide detection by copper complexes bearing anthracenyl and dansyl fluorophore ligands
Author
Lim, Mi HeeLippard, Stephen J.
Keywords
AQUEOUS-SOLUTION; PHOTOPHYSICAL PROPERTIES; CRYSTAL-STRUCTURE; NOBEL LECTURE; SENSORS; NO; CHEMISTRY; COBALT; IONS
Issue Date
2006-10
Publisher
AMER CHEMICAL SOC
Citation
INORGANIC CHEMISTRY, v.45, no.22, pp.8980 - 8989
Abstract
Anthrancenyl and dansyl fluorophore ligands [AnCH2pipCS 2K (1), Ds-Hen (2), Ds-HAMP (3), Ds-HAQ (4), and Ds-HAPP (5)] were prepared for coordination to CuII. Five Cu complexes, [Cu(AnCH 2pipCS2)2] (6), [Cu(Ds-en)2] (7), [Cu(Ds-AMP)2] (8), [Cu(Ds-AQ)2] (9), and [Cu(Ds-APP)(OTf)] (10), were synthesized as candidates for detecting nitric oxide (NO) by fluorescence and characterized by X-ray crystallography. A decrease in fluorescence compared to that of the free ligands (1-5) was measured following the formation of the corresponding five CuII complexes 6-10. Fluorescence was restored in the presence of NO in CH3OH/CH 2Cl2 solutions of the compounds. Complexes 7, 8, and 10 exhibited a fluorescence response to NO in pH 7.0 or 9.0 buffered aqueous solutions. Spectroscopic studies revealed that NO-induced fluorescence enhancement in these CuII complexes occurs by reduction to Cu I. The present studies demonstrate that CuII complexes are effective as fluorescent probes for detecting NO in both organic and aqueous environments.
URI
Go to Link
DOI
10.1021/ic0609913
ISSN
0020-1669
Appears in Collections:
PHY_Journal Papers
Files in This Item:
2-s2.0-33751402320.pdf Download

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU