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Lim, Mi Hee
MetalloNeuroChemistry Lab (MNCL)
Research Interests
  • Neurodegenerative disease, small molecule design, network between metal, proteins, and ROS

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Luminescent Properties of Ruthenium(II) Complexes with Sterically Expansive Ligands Bound to DNA Defects

Cited 21 times inthomson ciCited 16 times inthomson ci
Title
Luminescent Properties of Ruthenium(II) Complexes with Sterically Expansive Ligands Bound to DNA Defects
Author
McConnell, Anna J.Lim, Mi HeeOlmon, Eric D.Song, HangDervan, Elizabeth E.Barton, Jacqueline K.
Keywords
BULKY RHODIUM COMPLEX; BASE MISMATCHES; LIGHT-SWITCH; DIPYRIDOPHENAZINE COMPLEXES; BINDING; INTERCALATORS; RECOGNITION; METALLOINSERTION; D(GTCGAC)(2); MECHANISM
Issue Date
2012-11
Publisher
AMER CHEMICAL SOC
Citation
INORGANIC CHEMISTRY, v.51, no.22, pp.12511 - 12520
Abstract
A new family of ruthenium(II) complexes with sterically expansive ligands for targeting DNA defects was prepared, and their luminescent responses to base pair mismatches and/or abasic sites were investigated. Design of the complexes sought to combine the mismatch specificity of sterically expansive metalloinsertors, such as [Rh(bpy)2(chrysi)]3+ (chrysi = chrysene-5,6-quinone diimine), and the light switch behavior of [Ru(bpy) 2(dppz)]2+ (dppz = dipyrido[3,2-a:2',3'-c]phenazine). In one approach, complexes bearing analogues of chrysi incorporating hydrogen-bonding functionality similar to dppz were synthesized. While the complexes show luminescence only at low temperatures (77 K), competition experiments with [Ru(bpy)2(dppz)]2+ at ambient temperatures reveal that the chrysi derivatives preferentially bind DNA mismatches. In another approach, various substituents were introduced onto the dppz ligand to increase its steric bulk for mismatch binding while maintaining planarity. Steady state luminescence and luminescence lifetime measurements reveal that these dppz derivative complexes behave as DNA "light switches" but that the selectivity in binding and luminescence with mismatched/abasic versus well-matched DNA is not high. In all cases, luminescence depends sensitively upon structural perturbations to the dppz ligand.
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DOI
10.1021/ic3019524
ISSN
0020-1669
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PHY_Journal Papers
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