dc.citation.endPage |
415 |
- |
dc.citation.number |
1 |
- |
dc.citation.startPage |
413 |
- |
dc.citation.title |
JOURNAL OF ORGANIC CHEMISTRY |
- |
dc.citation.volume |
71 |
- |
dc.contributor.author |
Park, Cheol-Min |
- |
dc.date.accessioned |
2023-12-22T10:08:58Z |
- |
dc.date.available |
2023-12-22T10:08:58Z |
- |
dc.date.created |
2014-11-10 |
- |
dc.date.issued |
2006-01 |
- |
dc.description.abstract |
The basicity of an amine has a great impact on physicochemical properties and pharmacokinetics. To attenuate the basicity of morpholine, a bicyclic amine was designed and synthesized with the introduction of an additional β-oxygen. A transannular cyclization and reduction of a bridgehead α-chloro amine functionality produces the topographically unusual amine (pKa = 6.7) in good yield. |
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dc.identifier.bibliographicCitation |
JOURNAL OF ORGANIC CHEMISTRY, v.71, no.1, pp.413 - 415 |
- |
dc.identifier.doi |
10.1021/jo051982z |
- |
dc.identifier.issn |
0022-3263 |
- |
dc.identifier.scopusid |
2-s2.0-31144447125 |
- |
dc.identifier.uri |
https://scholarworks.unist.ac.kr/handle/201301/8557 |
- |
dc.identifier.url |
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=31144447125 |
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dc.identifier.wosid |
000234438700064 |
- |
dc.language |
영어 |
- |
dc.publisher |
AMER CHEMICAL SOC |
- |
dc.title |
Concise synthesis of 3,7-dioxa-9-aza-bicyclo[3,3,1]-nonane |
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dc.type |
Article |
- |
dc.description.isOpenAccess |
FALSE |
- |
dc.description.journalRegisteredClass |
scopus |
- |
dc.subject.keywordPlus |
TRANSANNULAR CYCLIZATION |
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dc.subject.keywordPlus |
AMINE BASICITY |
- |