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Park, Cheol-Min
Synthetic & Medicinal Chemistry Lab
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  • Organic synthesis, medicinal chemistry, chemical biology

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Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR

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dc.contributor.author Petros, Andrew M. ko
dc.contributor.author Huth, Jeffrey R. ko
dc.contributor.author Oost, Thorsten ko
dc.contributor.author Park, Cheol-Min ko
dc.contributor.author Ding, Hong ko
dc.contributor.author Wang, Xilu ko
dc.contributor.author Zhang, Haichao ko
dc.contributor.author Nimmer, Paul ko
dc.contributor.author Mendoza, Renaldo ko
dc.contributor.author Sun, Chaohong ko
dc.contributor.author Mack, Jamey ko
dc.contributor.author Walter, Karl ko
dc.contributor.author Dorwin, Sarah ko
dc.contributor.author Gramling, Emily ko
dc.contributor.author Ladror, Uri ko
dc.contributor.author Rosenberg, Saul H. ko
dc.contributor.author Elmore, Steven W. ko
dc.contributor.author Fesik, Stephen W. ko
dc.contributor.author Hajduk, Philip J. ko
dc.date.available 2014-11-11T00:15:57Z -
dc.date.created 2014-11-10 ko
dc.date.issued 2010-11 ko
dc.identifier.citation BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.22, pp.6587 - 6591 ko
dc.identifier.issn 0960-894X ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/8541 -
dc.description.abstract The Bcl-2 family of proteins plays a major role in the regulation of apoptosis, or programmed cell death. Overexpression of the anti-apoptotic members of this family (Bcl-2, Bcl-xL, and Mcl-1) can render cancer cells resistant to chemotherapeutic agents and therefore these proteins are important targets for the development of new anti-cancer agents. Here we describe the discovery of a potent, highly selective, Bcl-2 inhibitor using SAR by NMR and structure-based drug design which could serve as a starting point for the development of a Bcl-2 selective anti-cancer agent. Such an agent would potentially overcome the Bcl-xL mediated thrombocytopenia observed with ABT-263. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher PERGAMON-ELSEVIER SCIENCE LTD ko
dc.title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-77958048793 ko
dc.identifier.wosid 000283052900050 ko
dc.type.rims ART ko
dc.description.wostc 29 *
dc.description.scopustc 27 *
dc.date.tcdate 2015-05-06 *
dc.date.scptcdate 2014-11-10 *
dc.identifier.doi 10.1016/j.bmcl.2010.09.033 ko
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77958048793 ko
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