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DC Field | Value | Language |
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dc.citation.endPage | 6591 | - |
dc.citation.number | 22 | - |
dc.citation.startPage | 6587 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 20 | - |
dc.contributor.author | Petros, Andrew M. | - |
dc.contributor.author | Huth, Jeffrey R. | - |
dc.contributor.author | Oost, Thorsten | - |
dc.contributor.author | Park, Cheol-Min | - |
dc.contributor.author | Ding, Hong | - |
dc.contributor.author | Wang, Xilu | - |
dc.contributor.author | Zhang, Haichao | - |
dc.contributor.author | Nimmer, Paul | - |
dc.contributor.author | Mendoza, Renaldo | - |
dc.contributor.author | Sun, Chaohong | - |
dc.contributor.author | Mack, Jamey | - |
dc.contributor.author | Walter, Karl | - |
dc.contributor.author | Dorwin, Sarah | - |
dc.contributor.author | Gramling, Emily | - |
dc.contributor.author | Ladror, Uri | - |
dc.contributor.author | Rosenberg, Saul H. | - |
dc.contributor.author | Elmore, Steven W. | - |
dc.contributor.author | Fesik, Stephen W. | - |
dc.contributor.author | Hajduk, Philip J. | - |
dc.date.accessioned | 2023-12-22T06:40:28Z | - |
dc.date.available | 2023-12-22T06:40:28Z | - |
dc.date.created | 2014-11-10 | - |
dc.date.issued | 2010-11 | - |
dc.description.abstract | The Bcl-2 family of proteins plays a major role in the regulation of apoptosis, or programmed cell death. Overexpression of the anti-apoptotic members of this family (Bcl-2, Bcl-xL, and Mcl-1) can render cancer cells resistant to chemotherapeutic agents and therefore these proteins are important targets for the development of new anti-cancer agents. Here we describe the discovery of a potent, highly selective, Bcl-2 inhibitor using SAR by NMR and structure-based drug design which could serve as a starting point for the development of a Bcl-2 selective anti-cancer agent. Such an agent would potentially overcome the Bcl-xL mediated thrombocytopenia observed with ABT-263. | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.22, pp.6587 - 6591 | - |
dc.identifier.doi | 10.1016/j.bmcl.2010.09.033 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.scopusid | 2-s2.0-77958048793 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/8541 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77958048793 | - |
dc.identifier.wosid | 000283052900050 | - |
dc.language | 영어 | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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