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Park, Cheol-Min
Synthetic & Medicinal Chemistry Lab
Research Interests
  • Organic synthesis, medicinal chemistry, chemical biology


Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR

DC Field Value Language Petros, Andrew M. ko Huth, Jeffrey R. ko Oost, Thorsten ko Park, Cheol-Min ko Ding, Hong ko Wang, Xilu ko Zhang, Haichao ko Nimmer, Paul ko Mendoza, Renaldo ko Sun, Chaohong ko Mack, Jamey ko Walter, Karl ko Dorwin, Sarah ko Gramling, Emily ko Ladror, Uri ko Rosenberg, Saul H. ko Elmore, Steven W. ko Fesik, Stephen W. ko Hajduk, Philip J. ko 2014-11-11T00:15:57Z - 2014-11-10 ko 2010-11 ko
dc.identifier.citation BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.22, pp.6587 - 6591 ko
dc.identifier.issn 0960-894X ko
dc.identifier.uri -
dc.description.abstract The Bcl-2 family of proteins plays a major role in the regulation of apoptosis, or programmed cell death. Overexpression of the anti-apoptotic members of this family (Bcl-2, Bcl-xL, and Mcl-1) can render cancer cells resistant to chemotherapeutic agents and therefore these proteins are important targets for the development of new anti-cancer agents. Here we describe the discovery of a potent, highly selective, Bcl-2 inhibitor using SAR by NMR and structure-based drug design which could serve as a starting point for the development of a Bcl-2 selective anti-cancer agent. Such an agent would potentially overcome the Bcl-xL mediated thrombocytopenia observed with ABT-263. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-77958048793 ko
dc.identifier.wosid 000283052900050 ko
dc.type.rims ART ko
dc.description.wostc 29 *
dc.description.scopustc 27 * 2015-05-06 * 2014-11-10 *
dc.identifier.doi 10.1016/j.bmcl.2010.09.033 ko
dc.identifier.url ko
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