Curcumin Stimulates Glucose Uptake Through AMPK-p38 MAPK Pathways in L6 Myotube Cells
Cited 17 times inCited 17 times in
- Curcumin Stimulates Glucose Uptake Through AMPK-p38 MAPK Pathways in L6 Myotube Cells
- Kim, Ji Hae; Park, Ji Man; Kim, Eung-Kyun; Lee, Jung Ok; Lee, Soo Kyung; Jung, Jin Hee; You, Ga Young; Park, Sun Hwa; Suh, Pann-Ghill; Kim, Hyeon Soo
- ACTIVATED PROTEIN-KINASE; SKELETAL-MUSCLE; GLUT4 TRANSLOCATION; ANTIINFLAMMATORY AGENT; LIPID-PEROXIDATION; 3T3-L1 ADIPOCYTES; RAT-LIVER; TRANSPORT; INSULIN; ALPHA
- Issue Date
- JOURNAL OF CELLULAR PHYSIOLOGY, v.223, no.3, pp.771 - 778
- Curcumin has been shown to exert a variety of beneficial human health effects. However, mechanisms by which curcumin acts are poorly understood. In this study, we report that curcumin activated AMP-activated protein kinase (AMPK) and increased glucose uptake in rat L6 myotubes. In addition, curcumin activated the mitogen-activated protein kinase kinase (MEK)3/6-p38 mitogen-activated protein kinase (MAPK) signaling pathways in the downstream of the AMPK cascade. Moreover, inhibition of either AMPK or p38 MAPK resulted in blockage of curcumin-induced glucose uptake. Furthermore, the administration of curcumin to mice increased AMPK phosphorylation in the skeletal muscles. Taken together, these results indicate that the beneficial health effect of curcumin can be explained by its ability to activate AMPK-p38 MAPK pathways in skeletal muscles.
- ; Go to Link
- Appears in Collections:
- BME_Journal Papers
- Files in This Item:
can give you direct access to the published full text of this article. (UNISTARs only)
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.