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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Curcumin Stimulates Glucose Uptake Through AMPK-p38 MAPK Pathways in L6 Myotube Cells

Cited 17 times inthomson ciCited 17 times inthomson ci
Title
Curcumin Stimulates Glucose Uptake Through AMPK-p38 MAPK Pathways in L6 Myotube Cells
Author
Kim, Ji HaePark, Ji ManKim, Eung-KyunLee, Jung OkLee, Soo KyungJung, Jin HeeYou, Ga YoungPark, Sun HwaSuh, Pann-GhillKim, Hyeon Soo
Keywords
ACTIVATED PROTEIN-KINASE; SKELETAL-MUSCLE; GLUT4 TRANSLOCATION; ANTIINFLAMMATORY AGENT; LIPID-PEROXIDATION; 3T3-L1 ADIPOCYTES; RAT-LIVER; TRANSPORT; INSULIN; ALPHA
Issue Date
2010-06
Publisher
WILEY-BLACKWELL
Citation
JOURNAL OF CELLULAR PHYSIOLOGY, v.223, no.3, pp.771 - 778
Abstract
Curcumin has been shown to exert a variety of beneficial human health effects. However, mechanisms by which curcumin acts are poorly understood. In this study, we report that curcumin activated AMP-activated protein kinase (AMPK) and increased glucose uptake in rat L6 myotubes. In addition, curcumin activated the mitogen-activated protein kinase kinase (MEK)3/6-p38 mitogen-activated protein kinase (MAPK) signaling pathways in the downstream of the AMPK cascade. Moreover, inhibition of either AMPK or p38 MAPK resulted in blockage of curcumin-induced glucose uptake. Furthermore, the administration of curcumin to mice increased AMPK phosphorylation in the skeletal muscles. Taken together, these results indicate that the beneficial health effect of curcumin can be explained by its ability to activate AMPK-p38 MAPK pathways in skeletal muscles.
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DOI
10.1002/jcp.22093
ISSN
0021-9541
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BME_Journal Papers
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