Full metadata record
DC Field | Value | Language |
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dc.citation.number | 6 | - |
dc.citation.startPage | 100076 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 47 | - |
dc.contributor.author | Kim, Youni | - |
dc.contributor.author | Lee, Hyun-Kyung | - |
dc.contributor.author | Park, Kyeong-Yeon | - |
dc.contributor.author | Ismail, Tayaba | - |
dc.contributor.author | Lee, Hongchan | - |
dc.contributor.author | Ryu, Hong-Yeoul | - |
dc.contributor.author | Cho, Dong-Hyung | - |
dc.contributor.author | Kwon, Taeg Kyu | - |
dc.contributor.author | Park, Tae Joo | - |
dc.contributor.author | Kwon, Taejoon | - |
dc.contributor.author | Lee, Hyun-Shik | - |
dc.date.accessioned | 2024-08-12T10:05:19Z | - |
dc.date.available | 2024-08-12T10:05:19Z | - |
dc.date.created | 2024-07-23 | - |
dc.date.issued | 2024-06 | - |
dc.description.abstract | The actin -based cytoskeleton is considered a fundamental driving force for cell differentiation and development. Destrin (Dstn), a member of the actin-depolymerizing factor family, regulates actin dynamics by treadmilling actin filaments and increasing globular actin pools. However, the specific developmental roles of dstn have yet to be fully elucidated. Here, we investigated the physiological functions of dstn during early embryonic development using Xenopus laevis as an experimental model organism. dstn is expressed in anterior neural tissue and neural plate during Xenopus embryogenesis. Depleting dstn promoted morphants with short body axes and small heads. Moreover, dstn inhibition extended the neural plate region, impairing cell migration and distribution during neurulation. In addition to the neural plate, dstn knockdown perturbed neural crest cell migration. Our data suggest new insights for understanding the roles of actin dynamics in embryonic neural development, simultaneously presenting a new challenge for studying the complex networks governing cell migration involving actin dynamics. (c) 2024 The Author(s). Published by Elsevier Inc. on behalf of Korean Society for Molecular and Cellular Biology. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.47, no.6, pp.100076 | - |
dc.identifier.doi | 10.1016/j.mocell.2024.100076 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.scopusid | 2-s2.0-85195634957 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/83461 | - |
dc.identifier.wosid | 001253711900001 | - |
dc.language | 영어 | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.title | Actin depolymerizing factor destrin governs cell migration in neural development during Xenopus embryogenesis | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Cell Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | DYNAMICS | - |
dc.subject.keywordPlus | ORIGIN | - |
dc.subject.keywordPlus | RODS | - |
dc.subject.keywordPlus | N-COFILIN | - |
dc.subject.keywordPlus | ADF/COFILIN | - |
dc.subject.keywordPlus | NEURULATION | - |
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