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DC Field | Value | Language |
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dc.citation.endPage | 539 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 526 | - |
dc.citation.title | TRENDS IN GENETICS | - |
dc.citation.volume | 40 | - |
dc.contributor.author | Kang, Sukhyun | - |
dc.contributor.author | Yoo, Juyeong | - |
dc.contributor.author | Myung, Kyungjae | - |
dc.date.accessioned | 2024-07-24T13:35:12Z | - |
dc.date.available | 2024-07-24T13:35:12Z | - |
dc.date.created | 2024-07-23 | - |
dc.date.issued | 2024-06 | - |
dc.description.abstract | Proliferating cell nuclear antigen (PCNA) is a eukaryotic replicative DNA clamp. Furthermore, DNA -loaded PCNA functions as a molecular hub during DNA replication and repair. PCNA forms a closed homotrimeric ring that encircles the DNA, and association and dissociation of PCNA from DNA are mediated by clamp -loader complexes. PCNA must be actively released from DNA after completion of its function. If it is not released, abnormal accumulation of PCNA on chromatin will interfere with DNA metabolism. ATAD5 containing replication factor C -like complex (RLC) is a PCNA-unloading clamp -loader complex. ATAD5 deficiency causes various DNA replication and repair problems, leading to genome instability. Here, we review recent progress regarding the understanding of the action mechanisms of PCNA unloading complex in DNA replication/repair pathways. | - |
dc.identifier.bibliographicCitation | TRENDS IN GENETICS, v.40, no.6, pp.526 - 539 | - |
dc.identifier.doi | 10.1016/j.tig.2024.02.006 | - |
dc.identifier.issn | 0168-9525 | - |
dc.identifier.scopusid | 2-s2.0-85187988490 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/83296 | - |
dc.identifier.wosid | 001255263900001 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | PCNA cycling dynamics during DNA replication and repair in mammals | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.type.docType | Review | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | BASE EXCISION-REPAIR | - |
dc.subject.keywordPlus | FACTOR-C | - |
dc.subject.keywordPlus | MONOUBIQUITINATED PCNA | - |
dc.subject.keywordPlus | FORK REVERSAL | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | RECONSTITUTION | - |
dc.subject.keywordPlus | CELL NUCLEAR ANTIGEN | - |
dc.subject.keywordPlus | TELOMERES | - |
dc.subject.keywordPlus | SISTER-CHROMATID COHESION | - |
dc.subject.keywordPlus | ALTERNATIVE RFC COMPLEX | - |
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