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김지윤

Kim, Jiyun
Material Intelligence Lab.
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dc.citation.startPage 0032 -
dc.citation.title BIOMATERIALS RESEARCH -
dc.citation.volume 28 -
dc.contributor.author Choi, Cholong -
dc.contributor.author Yun, Eunhye -
dc.contributor.author Song, Minju -
dc.contributor.author Kim, Jiyun -
dc.contributor.author Son, Jae Sung -
dc.contributor.author Cha, Chaenyung -
dc.date.accessioned 2024-06-20T10:05:11Z -
dc.date.available 2024-06-20T10:05:11Z -
dc.date.created 2024-06-17 -
dc.date.issued 2024-06 -
dc.description.abstract In order to manipulate the complex behavior of cells in a 3-dimensional (3D) environment, it is important to provide the microenvironment that can accurately portray the complexity of highly anisotropic tissue structures. However, it is technically challenging to generate a complex microenvironment using conventional biomaterials that are mostly isotropic with limited bioactivity. In this study, the gelatin-hyaluronic acid hydrogel incorporated with aqueous-dispersible, short nanofibers capable of in situ alignment is developed to emulate the native heterogeneous extracellular matrix consisting of fibrous and non-fibrous components. The gelatin nanofibers containing magnetic nanoparticles, which could be aligned by external magnetic field, are dispersed and embedded in gelatin-hyaluronic acid hydrogel encapsulated with dermal fibroblasts. The aligned nanofibers via magnetic field could be safely integrated into the hydrogel, and the process could be repeated to generate larger 3D hydrogels with variable nanofiber alignments. The aligned nanofibers in the hydrogel can more effectively guide the anisotropic morphology (e.g., elongation) of dermal fibroblasts than random nanofibers, whereas myofibroblastic differentiation is more prominent in random nanofibers. At a given nanofiber configuration, the hydrogel composition having intermediate hyaluronic acid content induces myofibroblastic differentiation. These results indicate that modulating the degree of nanofiber alignment and the hyaluronic acid content of the hydrogel are crucial factors that critically influence the fibroblast phenotypes. The nanofiber-composite hydrogel capable of directional nanofiber alignment and tunable material composition can effectively induce a wide array of phenotypic plasticity in 3D cell culture. -
dc.identifier.bibliographicCitation BIOMATERIALS RESEARCH, v.28, pp.0032 -
dc.identifier.doi 10.34133/bmr.0032 -
dc.identifier.issn 1226-4601 -
dc.identifier.scopusid 2-s2.0-85195854306 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/83001 -
dc.identifier.wosid 001237621300001 -
dc.language 영어 -
dc.publisher AMER ASSOC ADVANCEMENT SCIENCE -
dc.title Multiscale Control of Nanofiber-Composite Hydrogel for Complex 3D Cell Culture by Extracellular Matrix Composition and Nanofiber Alignment -
dc.type Article -
dc.description.isOpenAccess TRUE -
dc.relation.journalWebOfScienceCategory Engineering, Biomedical; Materials Science, Biomaterials -
dc.relation.journalResearchArea Engineering; Materials Science -
dc.type.docType Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.description.journalRegisteredClass kci -
dc.subject.keywordPlus HYALURONIC-ACID -
dc.subject.keywordPlus MECHANICAL-PROPERTIES -
dc.subject.keywordPlus PROLIFERATION -
dc.subject.keywordPlus FIBROBLASTS -
dc.subject.keywordPlus GELATIN -
dc.subject.keywordPlus GROWTH -

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