Full metadata record
DC Field | Value | Language |
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dc.citation.startPage | gkae130 | - |
dc.citation.title | NUCLEIC ACIDS RESEARCH | - |
dc.contributor.author | Yang, Yuejun | - |
dc.contributor.author | Wang, Nan | - |
dc.contributor.author | Liu, Guoteng | - |
dc.contributor.author | Nan, Wencong | - |
dc.contributor.author | Wang, Bin | - |
dc.contributor.author | Gartner, Anton | - |
dc.contributor.author | Zhang, Hongtao | - |
dc.contributor.author | Hong, Ye | - |
dc.date.accessioned | 2024-04-04T10:05:11Z | - |
dc.date.available | 2024-04-04T10:05:11Z | - |
dc.date.created | 2024-04-03 | - |
dc.date.issued | 2024-02 | - |
dc.description.abstract | Accurate chromosome segregation during meiosis requires the establishment of at least one crossover (CO) between each pair of homologous chromosomes. CO formation depends on a group of conserved pro-CO proteins, which colocalize at CO-designated sites during late meiotic prophase I. However, it remains unclear whether these pro-CO proteins form a functional complex and how they promote meiotic CO formation in vivo. Here, we show that COSA-1, a key component required for CO formation, interacts with other pro-CO factors, MSH-5 and ZHP-3, via its N-terminal disordered region. Point mutations that impair these interactions do not affect CO designation, but they strongly hinder the accumulation of COSA-1 at CO-designated sites and result in defective CO formation. These defects can be partially bypassed by artificially tethering an interaction-compromised COSA-1 derivate to ZHP-3. Furthermore, we revealed that the accumulation of COSA-1 into distinct foci is required to assemble functional 'recombination nodules'. These prevent early CO-designated recombination intermediates from being dismantled by the RTEL-1 helicase and protect late recombination intermediates, such as Holliday junctions, until they are resolved by CO-specific resolvases. Altogether, our findings provide insight into COSA-1 mediated pro-CO complex assembly and its contribution to CO formation. Graphical Abstract | - |
dc.identifier.bibliographicCitation | NUCLEIC ACIDS RESEARCH, pp.gkae130 | - |
dc.identifier.doi | 10.1093/nar/gkae130 | - |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/81958 | - |
dc.identifier.wosid | 001173782600001 | - |
dc.language | 영어 | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | COSA-1 mediated pro-crossover complex formation promotes meiotic crossing over in C. elegans | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | ZMM PROTEINS | - |
dc.subject.keywordPlus | MEIOSIS | - |
dc.subject.keywordPlus | INTERFERENCE | - |
dc.subject.keywordPlus | CHROMOSOME | - |
dc.subject.keywordPlus | RECOMBINATION | - |
dc.subject.keywordPlus | MATURATION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | ANEUPLOIDY | - |
dc.subject.keywordPlus | RESOLUTION | - |
dc.subject.keywordPlus | REVEALS | - |
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