File Download

There are no files associated with this item.

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

Unraveling DNA Repair Processes In Vivo: Insights from Zebrafish Studies

Author(s)
Shin, UnbeomLee, Yoonsung
Issued Date
2023-09
DOI
10.3390/ijms241713120
URI
https://scholarworks.unist.ac.kr/handle/201301/81380
Citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.24, no.17, pp.13120
Abstract
The critical role of the DNA repair system in preserving the health and survival of living organisms is widely recognized as dysfunction within this system can result in a broad range of severe conditions, including neurodegenerative diseases, blood disorders, infertility, and cancer. Despite comprehensive research on the molecular and cellular mechanisms of DNA repair pathways, there remains a significant knowledge gap concerning these processes at an organismal level. The teleost zebrafish has emerged as a powerful model organism for investigating these intricate DNA repair mechanisms. Their utility arises from a combination of their well-characterized genomic information, the ability to visualize specific phenotype outcomes in distinct cells and tissues, and the availability of diverse genetic experimental approaches. In this review, we provide an in-depth overview of recent advancements in our understanding of the in vivo roles of DNA repair pathways. We cover a variety of critical biological processes including neurogenesis, hematopoiesis, germ cell development, tumorigenesis, and aging, with a specific emphasis on findings obtained from the use of zebrafish as a model system. Our comprehensive review highlights the importance of zebrafish in enhancing our understanding of the functions of DNA repair systems at the organismal level and paves the way for future investigations in this field.
Publisher
MDPI
ISSN
1661-6596
Keyword (Author)
zebrafishDNA repairgenome stabilityneurogenesishematopoiesisgerm cell developmentcanceraging
Keyword
FANCONI-ANEMIAEMBRYONIC LETHALITYTUMOR-FORMATIONHOMOLOGOUS RECOMBINATIONTARGETED DISRUPTIONGENOME STABILITYDAMAGEGENELEADSATM

qrcode

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.