Full metadata record
DC Field | Value | Language |
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dc.citation.number | 1 | - |
dc.citation.startPage | 8512 | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 14 | - |
dc.contributor.author | Han, Sang Mun | - |
dc.contributor.author | Park, Eun Seo | - |
dc.contributor.author | Park, Jeu | - |
dc.contributor.author | Nahmgoong, Hahn | - |
dc.contributor.author | Choi, Yoon Ha | - |
dc.contributor.author | Oh, Jiyoung | - |
dc.contributor.author | Yim, Kyung Min | - |
dc.contributor.author | Lee, Won Taek | - |
dc.contributor.author | Lee, Yun Kyung | - |
dc.contributor.author | Jeon, Yong Geun | - |
dc.contributor.author | Shin, Kyung Cheul | - |
dc.contributor.author | Huh, Jin Young | - |
dc.contributor.author | Choi, Sung Hee | - |
dc.contributor.author | Park, Jiyoung | - |
dc.contributor.author | Kim, Jong Kyoung | - |
dc.contributor.author | Kim, Jae Bum | - |
dc.date.accessioned | 2024-02-13T10:05:09Z | - |
dc.date.available | 2024-02-13T10:05:09Z | - |
dc.date.created | 2024-02-08 | - |
dc.date.issued | 2023-12 | - |
dc.description.abstract | Adipose tissue invariant natural killer T (iNKT) cells are a crucial cell type for adipose tissue homeostasis in obese animals. However, heterogeneity of adipose iNKT cells and their function in adipocyte turnover are not thoroughly understood. Here, we investigate transcriptional heterogeneity in adipose iNKT cells and their hierarchy using single-cell RNA sequencing in lean and obese mice. We report that distinct subpopulations of adipose iNKT cells modulate adipose tissue homeostasis through adipocyte death and birth. We identify KLRG1+ iNKT cells as a unique iNKT cell subpopulation in adipose tissue. Adoptive transfer experiments showed that KLRG1+ iNKT cells are selectively generated within adipose tissue microenvironment and differentiate into a CX3CR1+ cytotoxic subpopulation in obese mice. In addition, CX3CR1+ iNKT cells specifically kill enlarged and inflamed adipocytes and recruit macrophages through CCL5. Furthermore, adipose iNKT17 cells have the potential to secrete AREG, and AREG is involved in stimulating adipose stem cell proliferation. Collectively, our data suggest that each adipose iNKT cell subpopulation plays key roles in the control of adipocyte turnover via interaction with adipocytes, adipose stem cells, and macrophages in adipose tissue. Invariant natural killer T (iNKT) cells have recently been reported to play a key role in adipose tissue homeostasis. Here, the authors show that adipose tissue iNKT cells mediate immune responses that control adipocyte turnover in mice. | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.14, no.1, pp.8512 | - |
dc.identifier.doi | 10.1038/s41467-023-44181-3 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.scopusid | 2-s2.0-85180262878 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/81348 | - |
dc.identifier.wosid | 001129103900007 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.title | Unique adipose tissue invariant natural killer T cell subpopulations control adipocyte turnover in mice | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | NKT CELLS | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | MACROPHAGE RECRUITMENT | - |
dc.subject.keywordPlus | CHRONIC INFLAMMATION | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | CD1D | - |
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