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Kim, Jae-Ick
Neural Circuit and Neurodegenerative Disease Lab.
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dc.citation.conferencePlace KO -
dc.citation.conferencePlace 서울 COEX -
dc.citation.title 2019 International Conference: Korean Society for Molecular and Cellular Biology -
dc.contributor.author Kim, Hye Yun -
dc.contributor.author Yang, Yong Ryoul -
dc.contributor.author Hwang, Hongik -
dc.contributor.author Jang, Hyun-Jun -
dc.contributor.author Kim, Jeongyeon -
dc.contributor.author Yang, Esther -
dc.contributor.author Kim, Hyun -
dc.contributor.author Rhim, Hyewhon -
dc.contributor.author Kim, Jae-Ick -
dc.contributor.author Suh, Pann-Ghill -
dc.date.accessioned 2024-01-31T23:38:59Z -
dc.date.available 2024-01-31T23:38:59Z -
dc.date.created 2019-12-22 -
dc.date.issued 2019-10-01 -
dc.description.abstract Excitation/inhibition (E/I) balance plays a fundamental role in information processing of neural circuits. It coordinates various neural functions and dysregulated E/I balance causes multiple neurological disorders. Among them, epilepsy is associated with hyperexcitability of neurons caused by the deficits of GABAergic neuron or decreased GABAergic inhibition at synapses. Although many antiepileptic drugs are intended to improve GABAmediated inhibition via GABAergic interneurons, molecular mechanisms of E/I balance regulated by GABAergic neurons are not fully understood. Increasing evidence indicates that phospholipase C γ1 (PLCγ1) is involved in the generation of seizure, while the causal relationship between PLCγ1 and seizure has not been firmly established. Here, we show that genetic deletion of PLCγ1 in GABAergic neurons leads to spontaneous seizure. Plcg1F/F;Dlx5/6-Cre mice also exhibits other behavioral alterations, including hypoactivity, reduced anxiety, and fear memory deficit. Notably, inhibitory synaptic transmission as well as the number of inhibitory synapses are decreased in hippocampus. These findings suggest that PLCγ1 may be a key determinant of maintaining both inhibitory synapses and synaptic transmission, potentially contributing to the regulation of E/I balance in hippocampus. -
dc.identifier.bibliographicCitation 2019 International Conference: Korean Society for Molecular and Cellular Biology -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/79197 -
dc.language 영어 -
dc.publisher Korean Society for Molecular and Cellular Biology -
dc.title Deletion of PLCγ1 in GABAergic Neurons Leads to Spontaneous Seizure in Mice -
dc.type Conference Paper -
dc.date.conferenceDate 2019-09-30 -

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