dc.citation.conferencePlace |
KO |
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dc.citation.conferencePlace |
COEX |
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dc.citation.title |
2019 International conference: Korean Society for Molecular and Cellular Biology |
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dc.contributor.author |
Lee, Ah Reum |
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dc.contributor.author |
Kim, Kyu Min |
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dc.contributor.author |
Lee, Sang Kwon |
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dc.contributor.author |
Kweon, Yeong Cheon |
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dc.contributor.author |
Jeong, Su Ji |
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dc.contributor.author |
Lee, Yoon Yong |
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dc.contributor.author |
Jang, Ki Hyun |
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dc.contributor.author |
Park, Chan Young |
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dc.date.accessioned |
2024-01-31T23:38:55Z |
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dc.date.available |
2024-01-31T23:38:55Z |
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dc.date.created |
2020-01-10 |
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dc.date.issued |
2019-10-01 |
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dc.description.abstract |
Calcium signaling through store-operated Ca2+ entry (SOCE) plays essential roles in diverse cellular and physiological processes such as cell proliferation and differentiation. STIM and Orai are essential components enabling the reconstitution of Ca2+ release-activated Ca2+ (CRAC) channels that mediate SOCE. Recently, we reported that STIM2beta, STIM2 splice variant, plays a role in regulation of myogenesis. However, whether STIM2beta is involved in chondrogenesis remains unknown. In this study, we examined the mRNA expression of SOCE components by reverse transcription-polymerase chain reaction in differentiating chondrogenic ATDC5 cell, showing the increased mRNA expression level during chondrogenesis. And we generated STIM2beta knock-out ATDC5 cell with CRISPR-Cas9 system and confirmed that deletion of STIM2beta showed an altered calcium level and delayed chondrogenesis. These results showed that STIM2beta might play a positive role in chondrogenesis. Our study may shed light on SOCE mediated other cellular differentiation research. |
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dc.identifier.bibliographicCitation |
2019 International conference: Korean Society for Molecular and Cellular Biology |
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dc.identifier.uri |
https://scholarworks.unist.ac.kr/handle/201301/79193 |
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dc.language |
영어 |
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dc.publisher |
Korean Society for Molecular and Cellular Biology |
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dc.title |
STIM2beta enhances chondrogenesis. |
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dc.type |
Conference Paper |
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dc.date.conferenceDate |
2019-09-30 |
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