BROWSE

Related Researcher

Author's Photo

Cha, Chaenyung
Integrative Biomaterials Engineering
Research Interests
  • Biopolymer, nanocomposites, microfabrication, tissue engineering, drug delivery

ITEM VIEW & DOWNLOAD

Tuning the non-equilibrium state of a drug-encapsulated poly(ethylene glycol) hydrogel for stem and progenitor cell mobilization

Cited 11 times inthomson ciCited 10 times inthomson ci
Title
Tuning the non-equilibrium state of a drug-encapsulated poly(ethylene glycol) hydrogel for stem and progenitor cell mobilization
Author
Liang, YouyunJensen, Tor W.Roy, Edward J.Cha, ChaenyungDeVolder, Ross J.Kohman, Richie E.Zhang, Bao ZhongTextor, Kyle B.Rund, Lauretta A.Schook, Lawrence B.Tong, Yen WahKong, Hyunjoon
Keywords
Degradation rate; Granulocyte colony stimulating factor (GCSF); Michael-Addition; Poly(ethyleneimine); Rigidity
Issue Date
2011-03
Publisher
ELSEVIER SCI LTD
Citation
BIOMATERIALS, v.32, no.7, pp.2004 - 2012
Abstract
Injectable and biodegradable hydrogels have been increasingly studied for sustained drug delivery in various molecular therapies. However, it remains a challenge to attain desired delivery rate at injection sites due to local tissue pressures exerted on the soft hydrogels. Furthermore, there is often limited controllability of stiffness and degradation rates, which are key factors required for achieving desired drug release rate and therapeutic efficacy. This study presents a stiff and metastable poly(ethylene glycol) diacrylate (PEGDA)-poly (ethylene imine) (PEI) hydrogel which exhibits an elastic modulus equivalent to bulk plastic materials, and controllable degradation rate independent of its initial elastic modulus. Such unique stiffness was attained from the highly branched architecture of PEI, and the decoupled controllability of degradation rate was achieved by tuning the non-equilibrium swelling of the hydrogel. Furthermore, a single intramuscular administration of granulocyte colony stimulating factor (GCSF)-encapsulated PEGDA-PEI hydrogel extended the mobilization of mononuclear cells to four days. A larger yield of expanded CD34+ and CD31+ endothelial progenitor cells (EPCs) was also obtained as compared to the daily bolus administration. Overall, the hydrogel created in this study will be useful for the controlled and sustained delivery of a wide array of drug molecules.
URI
Go to Link
DOI
10.1016/j.biomaterials.2010.11.021
ISSN
0142-9612
Appears in Collections:
MSE_Journal Papers
Files in This Item:
2-s2.0-78650993581.pdf Download

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU