셀룰로오스와 2-메타크릴로일록세틸인포릴콜린을 이용한 친환경적이고 지속가능한 항균성 표면기술

Abstract

Extensive efforts have been devoted toward developing antibiofilm materials that can efficiently suppress bacterial attachment and subsequent biofilm formation. However, many of the previous approaches are based on non-biocompatible, non-degradable, and environmentally harmful synthetic materials. Herein, we report an efficient and sustainable biofilmresistant material that is made of a biocompatible, biodegradable, and naturally abundant cellulose derivate biopolymer. The biofilm-resistant material is made of cellulose acetate (CA) and possesses precisely defined nanoscale needle-like architectures on its surface. The CA nanoneedle array is further coated with a cell-membrane mimicking monomer of 2- methacryloryloxyethyl phosphorylcholine (MPC). Based on the synergetic integration of the bio- and environmentfriendly polymers of CA and MPC into nanoscale topography, the nanostructured CA not only effectively prevents bacterial attachment but also simultaneously exhibits strong bactericidal effects against both gram-positive and gramnegative bacteria. This natural cellulose derivative-based nanostructured material has strong potential as a biocompatible, and eco-friendly antibiofilm material for versatile uses in biomedical and industrial applications. The abstract should be written in English within 150 words using Times New Roman 10 point. Since the abstract is a shortened version of the paper, it should include the introduction, the main body, and the conclusion with the important ideas or contributions emphasized.