Photonic skin is one of the most promising technology for future applications to the wearable sensor devices. In this regard, many researchers in worldwide are looking into the development of the photonic skin. However, it is still challenging for adhesive patches to adhere to human's skin with high performance of sensing skills. Herein, an ultraadaptable, largearea, multi-pixel photonic skin based on a naturally abundant and durable biopolymer with a shape-memory, stimuli-responsive, and eye-readable properties, is presented. The wearable, large-scale, and multi-pixel photonic skin mainly consists of a photonic sensor made of meso-phase cholesteric hydroxypropyl cellulose and an ultraadaptable adhesive layer made of amorphous hydroxypropyl cellulose. It is demonstrated that multi-layered flexible architectures and the multi-phase cellulose derivative–based integrated photonic skins show not only seamlessly bonding to a wide range of biological and engineered surfaces, with a maximum of ≈180 times higher adhesion strengths compared to those of the polydimethylsiloxane adhesive, but also direct converting by spatiotemporal stimuli into visible color alterations in the largearea, multipixel array. These colorations can be simply turned into 3D strain mapping data for digital camera imaging.