Supramolecular polymerization using the host-guest interaction for the cancer therapy

Abstract

Supramolecular polymerization is consisting of noncovalent bonding. Noncovalent bonds are used to make large molecules such as proteins and nucleic acid, that is weaker than the covalent bond, but crucial for biochemical processes. Therefore, using the supramolecular polymerization, interfere in the biochemical process for induce the cell death. One of the supramolecular polymerization’s characteristic is host-guest interaction. Host molecules are connected with the targeting the cancer cell, and guest for disassemble the molecules before making the polymer. In addition, using the characteristic of the host-guest interaction, can change the guest molecules depend on the concentration, only in the cancer cell. With change the guest molecules, that can assist for the polymerization in the selective cell. Therefore, when the guest change occurs, the polymerization is starting to make the large molecules with the noncovalent bonding, and that polymerization can induce the cell death