Multivalent Interaction using Polymerization-induced Self-Assembly inside Mitochondria for senolytic effect

Abstract

The intracellular biomacromolecules including proteins play an important role to perform cellular function. Theses macromolecules are synthesized by the polymerization of small molecules but they have distinct properties that the small molecules do not have. Proteins which has well-ordered 3D or 4D structure, however, can perform various enzymatic activities and involve important cellular signaling by multivalent interaction. By mimicking the natural system, we found that polymerization of building block give a great platform to form assembled structure for multivalent interaction with bio-macromolecules. Thus, we developed polymerization induced self aseembly of KLAK sequence to bind with mitochondrial membrane via multivalent interaction for inducing dysfunction of mitochondria, leading to apoptosis of senescent cells specifically.