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Lee, Changwook
Structural Biology of Cellular Biochemistry Lab
Research Interests
  • Cell biology, structural biology, protein biochemistry, membrane biology, cancer biology

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Interactions of SV40 large T antigen and other viral proteins with retinoblastoma tumour suppressor

Cited 30 times inthomson ciCited 32 times inthomson ci
Title
Interactions of SV40 large T antigen and other viral proteins with retinoblastoma tumour suppressor
Author
Lee, ChangwookCho, Y
Issue Date
2002-03
Publisher
WILEY-BLACKWELL
Citation
REVIEWS IN MEDICAL VIROLOGY, v.12, no.2, pp.81 - 92
Abstract
Simian virus 40 large T antigen, human papilloma virus E7 and adenovirus E1A are all potent oncoproteins that can induce several types of tumours. One of the major functions of these oncoproteins is to interact with the retinoblastoma tumour suppressor protein, Rb, a master switch of the mammalian cell cycle, and to inactivate its function. Rb promotes cell-cycle arrest by recruiting and regulating proteins involved in the transcription of cell proliferation genes. The binding of viral oncoproteins to Rb disrupts the Rb-E2F complex, a central component in the Rb-mediated cell-cycle network. The crystal structures of Rb pocket-viral oncoprotein complexes indicate that the viral proteins recognise a highly conserved region in the Rb pocket through a common motif, LxCxE, and through other unique regions within each viral protein, Although the mechanism of Rb inactivation by viral proteins is not fully understood, information at the atomic level about the interactions between the Rb pocket and viral proteins is providing some insights into how viral proteins dissociate E2F from Rb and thus how they deregulate the cell cycle.
URI
https://scholarworks.unist.ac.kr/handle/201301/7290
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0036203739
DOI
10.1002/rmv.340
ISSN
1052-9276
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BIO_Journal Papers
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