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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 255 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 245 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 15 | - |
dc.contributor.author | Choi, Jang Hyun | - |
dc.contributor.author | Bae, SS | - |
dc.contributor.author | Park, JB | - |
dc.contributor.author | Ha, SH | - |
dc.contributor.author | Song, H | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Cocco, L | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.date.accessioned | 2023-12-22T11:12:57Z | - |
dc.date.available | 2023-12-22T11:12:57Z | - |
dc.date.created | 2014-10-14 | - |
dc.date.issued | 2003-04 | - |
dc.description.abstract | Phospholipase C-gamma1 (PLC-gamma1) plays pivotal roles in cellular growth and proliferation through its two Src homology (SH) 2 domains and its single SH3 domain, which interact with signaling molecules in response to various growth factors and hormones. However, the role of the SH domains in the growth factor-induced regulation of PLC-gamma1 is unclear. By peptide-mass fingerprinting analysis we have identified Cbl as a binding protein for the SH3 domain of PLC-gamma1 from rat pheochromatocyte PC12 cells. Association of Cbl with PLC-gamma1 was induced by epidermal growth factor (EGF) but not by nerve growth factor (NGF). Upon EGF stimulation, both Cbl and PLC-gamma1 were recruited to the activated EGF receptor through their SH2 domains. Mutation of the SH2 domains of either Cbl or PLC-gamma1 abrogated the EGF-induced interaction of PLC-gamma1 with Cbl, indicating that SH2-mediated translocation is essential for the association of PLC-gamma1 and Cbl. Overexpression of Cbl attenuated EGF-induced tyrosine phosphorylation and the subsequent activation of PLC-gamma1 by interfering competitively with the interaction between PLC-gamma1 and EGFR. Taken together, these results provide the first indications that Cbl may be a negative regulator of intracellular signaling following EGF-induced PLC-gamma1 activation. | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.15, no.2, pp.245 - 255 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.scopusid | 2-s2.0-0038266133 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/7284 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0038266133 | - |
dc.identifier.wosid | 000182588800016 | - |
dc.language | 영어 | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.title | Cbl competitively inhibits epidermal growth factor-induced activation of phospholipase C-gamma 1 | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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