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Cho, Hyungjoon
Biomedical Imaging Science and Engineering Lab(BISE)
Research Interests
  • Imaging tumor microenvironments, susceptibility contrast based MR structural imaging, ultra fast acquisitions of dynamic MR, algorithm/Hardware development for magnetic particle imaging

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Atrasentan (ABT-627) enhances perfusion and reduces hypoxia in a human tumor xenograft model

Cited 2 times inthomson ciCited 3 times inthomson ci
Title
Atrasentan (ABT-627) enhances perfusion and reduces hypoxia in a human tumor xenograft model
Author
Yang, Kwang MoRussell, JamesLupu, Mihaela E.Cho, HyungjoonLi, Xiao-FengKoutcher, Jason A.Ling, C. Clifton
Keywords
Atrasentan; EF5; HT29; Pimonidazole; Tumor hypoxia; Tumor perfusion
Issue Date
2009-10
Publisher
LANDES BIOSCIENCE
Citation
CANCER BIOLOGY & THERAPY, v.8, no.20, pp.1940 - 1946
Abstract
The endothelin-1 antagonist, atrasentan (ABT-627) was used to modify perfusion in the human tumor xenograft model, HT29, growing in nude mice. Atrasentan produced a significant increase in perfusion, as measured in vivo by Gd-DTPA DCE-MRI. Changes in tumor hypoxia were assessed by comparing the binding of two hypoxia tracers, pimonidazole and EF5 given before and after Atrasentan administration. In vehicle-treated controls, the distribution of EF5 and pimonidazole was very similar. However, Atrasentan treatment was associated with decreased uptake of the second hypoxia tracer (EF5), relative to the first (pimonidazole). Although Atrasentan had no independent effect on the growth of HT29 tumors, Atrasentan combined with 20 Gy radiation led to a modest but significant increase in tumor growth delay compared to radiation alone.
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DOI
10.4161/cbt.8.20.9595
ISSN
1538-4047
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BME_Journal Papers
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