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최장현

Choi, Jang Hyun
Lab of Diabetes and Metabolism Lab.
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dc.citation.endPage 481 -
dc.citation.number 7365 -
dc.citation.startPage 477 -
dc.citation.title NATURE -
dc.citation.volume 477 -
dc.contributor.author Choi, Jang Hyun -
dc.contributor.author Banks, Alexander S. -
dc.contributor.author Kamenecka, Theodore M. -
dc.contributor.author Busby, Scott A. -
dc.contributor.author Chalmers, Michael J. -
dc.contributor.author Kumar, Naresh -
dc.contributor.author Kuruvilla, Dana S. -
dc.contributor.author Shin, Youseung -
dc.contributor.author He, Yuanjun -
dc.contributor.author Bruning, John B. -
dc.contributor.author Marciano, David P. -
dc.contributor.author Cameron, Michael D. -
dc.contributor.author Laznik, Dina -
dc.contributor.author Jurczak, Michael J. -
dc.contributor.author Schuerer, Stephan C. -
dc.contributor.author Vidovic, Dusica -
dc.contributor.author Shulman, Gerald I. -
dc.contributor.author Spiegelman, Bruce M. -
dc.contributor.author Griffin, Patrick R. -
dc.date.accessioned 2023-12-22T05:47:02Z -
dc.date.available 2023-12-22T05:47:02Z -
dc.date.created 2014-10-14 -
dc.date.issued 2011-09 -
dc.description.abstract PPAR gamma is the functioning receptor for the thiazolidinedione (TZD) class of antidiabetes drugs including rosiglitazone and pioglitazone(1). These drugs are full classical agonists for this nuclear receptor, but recent data have shown that many PPAR gamma-based drugs have a separate biochemical activity, blocking the obesity-linked phosphorylation of PPAR gamma by Cdk5 (ref. 2). Here we describe novel synthetic compounds that have a unique mode of binding to PPAR gamma, completely lack classical transcriptional agonism and block the Cdk5-mediated phosphorylation in cultured adipocytes and in insulin-resistant mice. Moreover, one such compound, SR1664, has potent antidiabetic activity while not causing the fluid retention and weight gain that are serious side effects of many of the PPAR gamma drugs. Unlike TZDs, SR1664 also does not interfere with bone formation in culture. These data illustrate that new classes of antidiabetes drugs can be developed by specifically targeting the Cdk5-mediated phosphorylation of PPAR gamma. -
dc.identifier.bibliographicCitation NATURE, v.477, no.7365, pp.477 - 481 -
dc.identifier.doi 10.1038/nature10383 -
dc.identifier.issn 0028-0836 -
dc.identifier.scopusid 2-s2.0-80053131732 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/7222 -
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80053131732 -
dc.identifier.wosid 000295080500043 -
dc.language 영어 -
dc.publisher NATURE PUBLISHING GROUP -
dc.title Antidiabetic actions of a non-agonist PPAR gamma ligand blocking Cdk5-mediated phosphorylation -
dc.type Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordPlus ACTIVATED-RECEPTOR-GAMMA -
dc.subject.keywordPlus ADIPOCYTE DIFFERENTIATION -
dc.subject.keywordPlus SKELETAL-MUSCLE -
dc.subject.keywordPlus ROSIGLITAZONE -
dc.subject.keywordPlus EXPRESSION -
dc.subject.keywordPlus OBESITY -
dc.subject.keywordPlus POTENT -
dc.subject.keywordPlus THIAZOLIDINEDIONE -
dc.subject.keywordPlus PPAR-GAMMA-2 -
dc.subject.keywordPlus MODULATORS -

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