BROWSE

Related Researcher

Author's Photo

Bhak, Jong
KOrean GenomIcs Center(KOGIC)
Research Interests
  • Geromics, genomics, bioinformatics, protein Engineering, OMICS

ITEM VIEW & DOWNLOAD

Minke whale genome and aquatic adaptation in cetaceans

Cited 21 times inthomson ciCited 0 times inthomson ci
Title
Minke whale genome and aquatic adaptation in cetaceans
Author
Yim, Hyung-SoonCho, Yun SungGuang, XuanminKang, Sung GyunJeong, Jae-YeonCha, Sun-ShinOh, Hyun-MyungLee, Jae-HakYang, Eun ChanKwon, Kae KyoungKim, Yun JaeKim, Tae WanKim, WonduckJeon, Jeong HoKim, Sang-JinChoi, Dong HanJho, SungwoongKim, Hak-MinKo, JunsuKim, HyunminShin, Young-AhJung, Hyun-JuZheng, YuanWang, ZhuoChen, YanChen, MingJiang, AweiLi, ErliZhang, ShuHou, HaolongKim, Tae HyungYu, LiliLiu, ShaAhn, KungCooper, JessePark, Sin-GiHong, Chang PyoJin, WookKim, Heui-SooPark, ChankyuLee, KyooyeolChun, SungMorin, Phillip A.O'Brien, Stephen J.Lee, HangKimura, JumpeiMoon, Dae YeonManica, AndreaEdwards, JeremyKim, Byung ChulKim, SangsooWang, JunBhak, Jong HwaLee, Hyun SookLee, Jung-Hyun
Keywords
RNA-SEQ; MAXIMUM-LIKELIHOOD; TURSIOPS-TRUNCATUS; PROTEIN FAMILIES; DATABASE; SEQUENCES; ALIGNMENT; GENES; IDENTIFICATION; STRESS
Issue Date
2014-01
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE GENETICS, v.46, no.1, pp.88 -
Abstract
The shift from terrestrial to aquatic life by whales was a substantial evolutionary event. Here we report the whole-genome sequencing and de novo assembly of the minke whale genome, as well as the whole-genome sequences of three minke whales, a fin whale, a bottlenose dolphin and a finless porpoise. Our comparative genomic analysis identified an expansion in the whale lineage of gene families associated with stress-responsive proteins and anaerobic metabolism, whereas gene families related to body hair and sensory receptors were contracted. Our analysis also identified whale-specific mutations in genes encoding antioxidants and enzymes controlling blood pressure and salt concentration. Overall the whale-genome sequences exhibited distinct features that are associated with the physiological and morphological changes needed for life in an aquatic environment, marked by resistance to physiological stresses caused by a lack of oxygen, increased amounts of reactive oxygen species and high salt levels.
URI
https://scholarworks.unist.ac.kr/handle/201301/7214
DOI
10.1038/ng.2835
ISSN
1061-4036
Appears in Collections:
BME_Journal Papers
Files in This Item:
000329113500019.pdf Download

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU