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Park, Jiyoung
Molecular Metabolism Laboratory (MML)
Research Interests
  • Obesity, diabetes, adipose tissue, cancer, cancer-associated adipocyte, dermal adipocyte, metabolic memory

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Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis - Liver X receptor-mediated lipotoxicity in pancreatic beta-cells

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dc.contributor.author Choe, Sung Sik ko
dc.contributor.author Choi, A. Hyun ko
dc.contributor.author Lee, Joo-Won ko
dc.contributor.author Kim, Kang Ho ko
dc.contributor.author Chung, Jun-Jae ko
dc.contributor.author Park, Jiyoung ko
dc.contributor.author Lee, Kyeong-Min ko
dc.contributor.author Park, Keun-Gyu ko
dc.contributor.author Lee, In-Kyu ko
dc.contributor.author Kim, Jae Bum ko
dc.date.available 2014-10-16T01:42:01Z -
dc.date.created 2014-10-13 ko
dc.date.issued 2007-06 ko
dc.identifier.citation DIABETES, v.56, no.6, pp.1534 - 1543 ko
dc.identifier.issn 0012-1797 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/7182 -
dc.description.abstract Liver X receptor (LXR)α and LXRβ play important roles in fatty acid metabolism and cholesterol homeostasis. Although the functional roles of LXR in the liver, intestine, fat, and macrophages are well established, its role in pancreatic β-cells has not been clearly defined. In this study, we revealed that chronic activation of LXR contributes to lipotoxicity-induced β-cell dysfunction. We observed significantly elevated expression of LXR in the islets of diabetic rodent models, including fa/fa ZDF rats, OLETF rats, and db/db mice. In primary pancreatic islets and INS-1 insulinoma cells, activation of LXR with a synthetic ligand, T0901317, stimulated expression of the lipogenic genes ADD1/SREBP1c, FAS, and ACC and resulted in increased intracellular lipid accumulation. Moreover, chronic LXR activation induced apoptosis in pancreatic islets and INS-1 cells, which was synergistically promoted by high glucose conditions. Taken together, we suggest lipid accumulation caused by chronic activation of LXR in β-cells as a possible cause of β-cell lipotoxicity, a key step in the development of type 2 diabetes. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher AMER DIABETES ASSOC ko
dc.title Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis - Liver X receptor-mediated lipotoxicity in pancreatic beta-cells ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-34249682775 ko
dc.identifier.wosid 000246930000006 ko
dc.type.rims ART ko
dc.description.wostc 61 *
dc.description.scopustc 61 *
dc.date.tcdate 2015-05-06 *
dc.date.scptcdate 2014-10-13 *
dc.identifier.doi 10.2337/db06-1059 ko
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34249682775 ko
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