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DC Field | Value | Language |
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dc.citation.endPage | 890 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 876 | - |
dc.citation.title | CELL | - |
dc.citation.volume | 136 | - |
dc.contributor.author | Park, Chan Young | - |
dc.contributor.author | Hoover, Paul J. | - |
dc.contributor.author | Mullins, Franklin M. | - |
dc.contributor.author | Bachhawat, Priti | - |
dc.contributor.author | Covington, Elizabeth D. | - |
dc.contributor.author | Raunser, Stefan | - |
dc.contributor.author | Walz, Thomas | - |
dc.contributor.author | Garcia, K. Christopher | - |
dc.contributor.author | Dolmetsch, Ricardo E. | - |
dc.contributor.author | Lewis, Richard S. | - |
dc.date.accessioned | 2023-12-22T08:08:50Z | - |
dc.date.available | 2023-12-22T08:08:50Z | - |
dc.date.created | 2014-10-13 | - |
dc.date.issued | 2009-03 | - |
dc.description.abstract | Store-operated Ca2+ channels activated by the depletion of Ca2+ from the endoplasmic reticulum (ER) are a major Ca2+ entry pathway in nonexcitable cells and are essential for T cell activation and adaptive immunity. After store depletion, the ER Ca2+ sensor STIM1 and the CRAC channel protein Orai1 redistribute to ER-plasma membrane (PM) junctions, but the fundamental issue of how STIM1 activates the CRAC channel at these sites is unresolved. Here, we identify a minimal, highly conserved 107-aa CRAC activation domain (CAD) of STIM1 that binds directly to the N and C termini of Orai1 to open the CRAC channel. Purified CAD forms a tetramer that clusters CRAC channels, but analysis of STIM1 mutants reveals that channel clustering is not sufficient for channel activation. These studies establish a molecular mechanism for store-operated Ca2+ entry in which the direct binding of STIM1 to Orai1 drives the accumulation and the activation of CRAC channels at ER-PM junctions. | - |
dc.identifier.bibliographicCitation | CELL, v.136, no.5, pp.876 - 890 | - |
dc.identifier.doi | 10.1016/j.cell.2009.02.014 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.scopusid | 2-s2.0-61349137530 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/7172 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=61349137530 | - |
dc.identifier.wosid | 000263930900011 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1 | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | OPERATED CA2+ ENTRY | - |
dc.subject.keywordPlus | STROMAL INTERACTION MOLECULE-1 | - |
dc.subject.keywordPlus | PLASMA-MEMBRANE | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM | - |
dc.subject.keywordPlus | STORE DEPLETION | - |
dc.subject.keywordPlus | CALCIUM-CHANNELS | - |
dc.subject.keywordPlus | PORE SUBUNIT | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | I-CRAC | - |
dc.subject.keywordPlus | OLIGOMERIZATION | - |
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