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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 7174 | - |
dc.citation.number | 24 | - |
dc.citation.startPage | 7165 | - |
dc.citation.title | NUCLEIC ACIDS RESEARCH | - |
dc.citation.volume | 31 | - |
dc.contributor.author | Lee, YS | - |
dc.contributor.author | Lee, HH | - |
dc.contributor.author | Park, Jiyoung | - |
dc.contributor.author | Yoo, EJ | - |
dc.contributor.author | Glackin, CA | - |
dc.contributor.author | Choi, YI | - |
dc.contributor.author | Jeon, SH | - |
dc.contributor.author | Seong, RH | - |
dc.contributor.author | Park, SD | - |
dc.contributor.author | Kim, JB | - |
dc.date.accessioned | 2023-12-22T11:08:14Z | - |
dc.date.available | 2023-12-22T11:08:14Z | - |
dc.date.created | 2014-10-13 | - |
dc.date.issued | 2003-12 | - |
dc.description.abstract | Adipocyte determination and differentiation dependent factor 1 (ADD1)/sterol regulatory element binding protein isoform (SREBP1c) is a key transcription factor in fatty acid metabolism and insulin-dependent gene expression. Although its transcriptional and post-translational regulation has been extensively studied, its regulation by interacting proteins is not well understood. To identify cellular proteins that associate with ADD1/SREBP1c, we employed the yeast two-hybrid system with an adipocyte cDNA library. Using the N-terminal domain of ADD1/SREBP1c as bait, we identified Twist2 (also known as Dermo-1), a basic helix-loop-helix (bHLH) protein, as a novel ADD1/SREBP1c interacting protein. Over-expression of Twist2 strongly repressed the transcriptional activity of ADD1/SREBP1c, primarily by reducing its binding to target sequences. Inhibition of histone deacetylase (HDAC) activity with HDAC inhibitors relieved this repression. Our data suggest that physical interaction between Twist2 and ADD1/SREBP1c attenuates transcriptional activation by ADD1/SREBP1c by inhibiting its binding to DNA, and that this inhibition is at least partly dependent on chromatin modification by HDACs. | - |
dc.identifier.bibliographicCitation | NUCLEIC ACIDS RESEARCH, v.31, no.24, pp.7165 - 7174 | - |
dc.identifier.doi | 10.1093/nar/gkg934 | - |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.scopusid | 2-s2.0-10744220537 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/7156 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=10744220537 | - |
dc.identifier.wosid | 000187659000012 | - |
dc.language | 영어 | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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