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Kang, Byoung Heon
Cancer Biology Lab
Research Interests
  • Mitochondrial chaperones, cancer biology, cell death, metabolism, cancer stem cells, cancer therapeutics development

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Effects of mutations in the C-terminal region of NIa protease on cis-cleavage between NIa and NIb

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dc.contributor.author Kim, DH ko
dc.contributor.author Han, JS ko
dc.contributor.author Lew, JS ko
dc.contributor.author Kim, SS ko
dc.contributor.author Kang, Byoung Heon ko
dc.contributor.author Hwang, DC ko
dc.contributor.author Jang, DS ko
dc.contributor.author Kim, W ko
dc.contributor.author Song, BD ko
dc.contributor.author Choi, KY ko
dc.date.available 2014-10-13T01:27:59Z -
dc.date.created 2014-10-10 ko
dc.date.issued 1998-02 ko
dc.identifier.citation VIROLOGY, v.241, no.1, pp.94 - 100 ko
dc.identifier.issn 0042-6822 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/7132 -
dc.description.abstract Mutational analyses were carried out to investigate whether the nuclear inclusion protein a (NIa) C-terminal amino acids of turnip mosaic potyvirus play any roles in the cis-cleavage between NIa and NIb. The processing rate of the NIa-NIb junction sequence was decreased significantly by either V240D or Q243A mutation while little affected by F226D, V228E, K230E, 1232D, or L235D mutation. The mutation of W212S, G213S, or 1217D abolishing the cleavage at the NIb-CP or 6K1-cylindrical inclusion protein junction sequence decreased the processing rate to half the level of that of the wild type. Deletion of the C-terminal one (K230), two (S229 and K230), three (S229 to L231), or six amino acids (S229 to D234) as well as the insertion of five giycines between S229 and K230 or between S220 and Q221 did not affect significantly the cleavage while the deletion of 20 amino acids (Q218 to S237) decreased the processing rate to 73% of that of the wild type. These results rule out the possibility that the C-terminal region plays a role as a spacer in right placement of the NIa-NIb junction sequence and demonstrate that the C-terminal 20 amino acids from Q218 to S237 are not crucial for the cis-cleavage of the NIa-NIb junction sequence. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher ACADEMIC PRESS INC ELSEVIER SCIENCE ko
dc.title Effects of mutations in the C-terminal region of NIa protease on cis-cleavage between NIa and NIb ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-0032006499 ko
dc.identifier.wosid 000071836100009 ko
dc.type.rims ART ko
dc.description.wostc 10 *
dc.description.scopustc 10 *
dc.date.tcdate 2015-05-06 *
dc.date.scptcdate 2014-10-10 *
dc.identifier.doi 10.1006/viro.1997.8938 ko
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0032006499 ko
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