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Kim, Jeong Beom
Molecular Biomedicine Lab
Research Interests
  • Patient-specific stem cells, induced pluripotent stem (iPS) cells, direct conversion, 3D bio-printing, Regenerative medicine, Patient-specific drug screening

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Oct4-Induced Pluripotency in Adult Neural Stem Cells

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Title
Oct4-Induced Pluripotency in Adult Neural Stem Cells
Author
Kim, Jeong BeomSebastiano, VittorioWu, GuangmingArauzo-Bravo, Marcos J.Sasse, PhilippGentile, LucaKo, KinarmRuau, DavidEhrich, Mathiasvan den Boom, DirkMeyer, JohannHuebner, KarinBernemann, ChristofOrtmeier, ClaudiaZenke, MartinFleischmann, Bernd K.Zaehres, HolmSchoeler, Hans R.
Issue Date
2009-02
Publisher
CELL PRESS
Citation
CELL, v.136, no.3, pp.411 - 419
Abstract
The four transcription factors Oct4, Sox2, Klf4, and c-Myc can induce pluripotency in mouse and human fibroblasts. We previously described direct reprogramming of adult mouse neural stem cells (NSCs) by Oct4 and either Klf4 or c-Myc. NSCs endogenously express Sox2, c-Myc, and Klf4 as well as several intermediate reprogramming markers. Here we report that exogenous expression of the germline-specific transcription factor Oct4 is sufficient to generate pluripotent stem cells from adult mouse NSCs. These one-factor induced pluripotent stem cells (1F iPS) are similar to embryonic stem cells in vitro and in vivo. Not only can these cells can be efficiently differentiated into NSCs, cardiomyocytes, and germ cells in vitro, but they are also capable of teratoma formation and germline transmission in vivo. Our results demonstrate that Oct4 is required and sufficient to directly reprogram NSCs to pluripotency.
URI
https://scholarworks.unist.ac.kr/handle/201301/7092
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=59349108302
DOI
10.1016/j.cell.2009.01.023
ISSN
0092-8674
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BME_Journal Papers
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